• Started anticoagulation therapy |
• Major hemorrhage, defined as bleeding resulting in a drop in hemoglobin greater than 20 g/L or bleeding requiring blood transfusion with other clinical evidence or suspicion of bleeding |
• Undergone major surgery |
• Diagnosis of intraspinal or intracranial neoplasm |
• Patient decision to withdraw |
• Active pericarditis |
• Missed two or more consecutive weekly study treatment sessions |