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Table 4 Reasons for Discontinuing Patient Study Drug

From: Prevention of catheter lumen occlusion with rT-PA versus heparin (Pre-CLOT): study protocol of a randomized trial [ISRCTN35253449]

• Started anticoagulation therapy
• Major hemorrhage, defined as bleeding resulting in a drop in hemoglobin greater than 20 g/L or bleeding requiring blood transfusion with other clinical evidence or suspicion of bleeding
• Undergone major surgery
• Diagnosis of intraspinal or intracranial neoplasm
• Patient decision to withdraw
• Active pericarditis
• Missed two or more consecutive weekly study treatment sessions