Table 1 Study inclusion criteria

• Age 18 to 40 years

• GFR ≥ 70 ml/min (Cockcroft - Gault formula)

• Diagnosis of ADPKD:

   ○ Positive family history for ADPKD

■ patients < 30 years: ≥ 2 cysts in either kidney

■ patients ≥ 30 years: ≥ 2 cysts in each kidney

   ○ Negative family history for ADPKD but sonographically cystic kidney disease: proof of a mutation in the PKD1 or PKD2 gene is required (Athena Diagnostics, Inc., Worcester, MA, USA)

• Documented kidney volume enlargement (MRI volumetry)

• Signed informed consent