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Table 1 Study inclusion criteria

From: Clinical proof-of-concept trial to assess the therapeutic effect of sirolimus in patients with autosomal dominant polycystic kidney disease: SUISSE ADPKD study

• Age 18 to 40 years
• GFR ≥ 70 ml/min (Cockcroft - Gault formula)
• Diagnosis of ADPKD:
    Positive family history for ADPKD
■ patients < 30 years: ≥ 2 cysts in either kidney
■ patients ≥ 30 years: ≥ 2 cysts in each kidney
    Negative family history for ADPKD but sonographically cystic kidney disease: proof of a mutation in the PKD1 or PKD2 gene is required (Athena Diagnostics, Inc., Worcester, MA, USA)
• Documented kidney volume enlargement (MRI volumetry)
• Signed informed consent