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Figure 3 | BMC Nephrology

Figure 3

From: Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2and Cdk2

Figure 3

Functional expression of PKD2 in HEK293 cells. Whole cell step currents in vector-only (A and F), wild type PKD2- (B and G), or PKD2(742X)-stably transfected HEK293 cells (C and H) in normal extracellular tyrode solution (130K+:135Na+/2 Ca2+/5.4 K+) (A-C) or symmetrical K+ (130K+:130K+) (F-H). Current-voltage (I–V) curves derived from a step protocol in untransfected (black squares), mock-transfected (vector control) (black circles), WT PKD2- (red circles), or PKD2 (R742X)-stably transfected HEK293 cells (green circles) in normal extracellular tyrode solution (D) or symmetrical K+ (I). ''*'': p < 0.05.

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