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Table 1 Dialysis populations: demographics and haematological data.

From: Serum free light chain measurement aids the diagnosis of myeloma in patients with severe renal failure

 

Whole population (n-142)

Multiple myeloma patients (n-41)

Male – percentages

39%

56%

Ethnicity – percentages

  

Caucasian

85%

85%

Afro-Caribbean

4%

5%

South-Asian

8%

10%

Other

3%

0%

Median age in years (range)

70 (19–88)

67 (38–84)

Median serum creatinine μmol/L (range)

529 (274–1758)

622 (302–3000)*

Myeloma type – percentages

  

IgGκ

 

24%

IgGλ

 

22%

IgAκ

 

7%

IgAλ

 

15%

IgMλ

 

2%**

Free κ only

 

10%

Free λ only

 

19%

κ light chain class (overall) %

 

41%

  1. *Serum creatinine significantly higher in multiple myeloma patients compared with the dialysis population as a whole, P < 0.02. **One patient with known chronic lymphocytic leukaemia, in remission, presented with acute renal failure and biopsy proven cast nephropathy. Investigation identified an intact IgM band on immunofixation electrophoresis with an associated λ FLC, bone marrow examination provided a haematological diagnosis of IgM myeloma.