Table 2 Outcome measures at baseline, 6 and 12 months

Primary Outcome Measures

   Arterial stiffness – aortic pulse wave velocity (PWV)

   Oxidative stress – plasma isoprostanes

   Inflammation – plasma pentraxin 3

Secondary Outcome Measures

   Arterial stiffness – augmentation index (AIx)

   Arterial stiffness – carotid artery intimal medial thickness (CMIT)

   Left ventricular overload – central pulse pressure

   Vascular function – brachial artery reactivity (BAR)

   Oxidative stress – plasma protein carbonyls

Antioxidant status – plasma total antioxidant capacity,

- plasma antioxidant enzyme activities

- plasma antioxidant enzyme activities

   Inflammation – C reactive protein, IL-6, IL-8, IL-10 and TNF-alpha

   Additional blood measures – full blood profile, electrolytes, liver function

- lipid profile

- plasma immunosuppressant levels

- eGFR

   Adverse events

   Concomitant therapy

   Self reported health – SF 36

   Physical Activity – items from the Active Australia questionnaire

   Nutrition – four day diet diary