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Table 2 Partial correlations of cystatin C and creatinine-based eGFR with inflammatory and procoagulant markers at the baseline visit of the MESA study, stratified by presence of chronic kidney disease

From: Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: A cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)

Marker of Kidney Function Inflammatory Marker
  CRP (N = 6750) IL-6 (N = 6622) TNF-αR1 (N = 995) ICAM-1 (N = 2611) Fibrinogen (N = 6750) Factor VIII (N = 6750)
Cystatin C 0.075* 0.156* 0.748* 0.209* 0.137* 0.112*
Creatinine-based eGFR -0.019 -0.003 -0.285* 0.025 -0.059* -0.034*
Persons with CKD       
   Cystatin C 0.116* 0.230* 0.903* 0.160* 0.248* 0.140*
   Creatinine-based eGFR -0.101* -0.139* -0.763* -0.035 -0.286* -0.146*
Persons without CKD       
   Cystatin C 0.085* 0.180* 0.557*† 0.261* 0.111*† 0.085*
   Creatinine-based eGFR -0.004‡ 0.025‡ -0.168*‡ 0.027 -0.021‡ 0.017‡
  1. Partial correlations adjusted for age, gender, race/ethnicity, and BMI
  2. Chronic kidney disease (CKD) defined as eGFR < 60 mL/min/1.73 m2
  3. * Correlation is significant at the 0.01 level (2-tailed).
  4. † Correlation between cystatin C and the biomarker is significantly stronger among participants with CKD
  5. ‡ Correlation between creatinine-based eGFR and the biomarker is significantly stronger among participants with CKD