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Table 3 Adjusted mean biomarker levels at the baseline visit of the MESA study, in participants with and without chronic kidney disease

From: Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: A cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)

Biomarker (units) CKD Mean levels (95% CI) No CKD Mean levels (95% CI) P-value
CRP (log mg/L) N = 6750 0.81 (0.73, 0.89) 0.63 (0.61, 0.66) <0.001
IL-6 (log pg/mL) N = 6622 0.37 (0.33, 0.41) 0.19 (0.18, 0.21) <0.001
TNF-αR1 (pg/mL) N = 995 1.90 (1.76, 2.03) 1.23 (1.22, 1.25) <0.001
ICAM-1 (ng/mL) N = 2611 281 (271, 290) 274 (271, 277) 0.19
Fibrinogen (mg/dL) N = 6750 363 (360, 372) 345 (343, 346) <0.001
Factor VIII (%) N = 6750 187 (181, 193) 161 (160, 163) <0.001
  1. All biomarker models adjusted for age, gender, race/ethnicity, smoking status, BMI, diabetes, hypertension, LDL, HDL, and use of statins
  2. Chronic kidney disease (CKD) defined as eGFR < 60 mL/min/1.73 m2