Apolipoprotein L1, income and early kidney damage

BMC Nephrology

Table 4 Sensitivity analysis

Model – Variables	Odds Ratios for eGFR < 75(95% Confidence Interval)n = 51 events		P interaction ( APOL1 x SES measure)	Odds Ratios for Elevated ACR(95% Confidence Interval) n = 21 events		P interaction ( APOL1 x SES measure)
	High-risk versus Low-risk APOL1 variants	Low SES versus Higher SES Group		High-risk versus Low-risk APOL1 variants	Low SES versus Higher SES Group
*Additive Models*
APOL1, Education	1.60 (1.00, 2.57)	1.95 (1.50, 2.54)	0.4	3.89 (2.28, 6.63)	1.68 (0.34, 8.23)	0.823
APOL1, Employment	2.06 (1.53, 2.78)	4.64 (3.40, 6.33)	0.017*	3.12 (1.73, 5.63)	1.32 (0.83, 2.08)	0.894
APOL1, Health Insurance	1.92 (1.27, 2.90)	1.00 (0.53, 1.89)	0.662	3.04 (1.65, 5.60)	0.56 (0.14, 2.28)	**could not be determined
APOL1, Regular Health Care Source	1.91 (1.15, 3.17)	0.54 (0.31, 0.94)	0.871	3.09 (1.56, 6.13)	0.64 (0.14, 2.86)	**could not be determined

Note: Data on employment, health insurance and regular source of health care were missing for 11% in the eGFR < 75 models and for 17% of the ACR models. For the eGFR < 75 models, these variables were missing in 16% of the high-risk APOL1 group compared to 10% of the low-risk group. For the ACR models, these variables were missing in 25% of the high-risk APOL1 group compared to 15% of the low-risk group.
*High-risk APOL1 was associated with eGFR < 75 only among those who were unemployed [3.54 (1.98, 6.35)] compared to the employed [0.45 (0.13, 1.58)].
**Imbalance in strata.
Association of APOL1 and Other Indicators of Socioeconomic Status (SES) with eGFR < 75 ml/min/1.73 m² or Sex-Specific Elevated Albumin-to-Creatinine Ratio (ACR).

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