From: TWEAK/Fn14 system and crescent formation in IgA nephropathy
Characteristics | IgAN Group 1 ( n  = 39) | IgAN Group 2 ( n  = 39) | IgAN Group 3 ( n  = 38) | P value |
---|---|---|---|---|
pg/mgCr, median (IQR) | pg/mgCr, median (IQR) | pg/mgCr, median (IQR) | ||
50.7 (21.1, 65.3) | 96.4 (81.2, 105.7) | 163.8 (147.1, 190.6) | ||
Clinical | ||||
Age (years) | 33.2 ± 10.2 | 32.9 ± 10.9 | 36.1 ± 11.6 | 0.39 |
Men, n (%) | 16 (41.0) | 25 (64) | 12 (32) | 0.01 |
BMI (kg/m2) | 21.4 ± 2.7 | 22.4 ± 2.9 | 21.4 ± 3.3 | 0.22 |
Mean arterial pressure (mmHg) | 82.8 ± 11.2 | 84.1 ± 19.2 | 84.6 ± 9.5 | 0.84 |
eGFR (ml/min per 1.73 m2) | 83.3 ± 25.8 | 82.4 ± 35.2 | 80.0 ± 25.8 | 0.88 |
CKD Stages 1, 2, 3, and 4 (KDOQI) (%) | ||||
Stage 1: >90 | 15 (38.5) | 9 (23.7) | 13 (34.2) | 0.35 |
Stage 2: 60-89 | 16 (41.0) | 23 (60.5) | 15 (39.5) | |
Stage 3: 30-59 | 7 (17.9) | 6 (15.8) | 10 (26.3) | |
Stage 4: 15-29 | 1 (2.6) | 0 (0) | 0 (0) | |
Urinary protein excretion (g/gCr) | 0.28 ± 0.30 | 0.51 ± 0.60 | 1.03 ± 1.28 A,B | <0.001 |
class 0: <0.30 | 24 (61.5) | 20 (51.3) | 11 (28.9) | 0.004 |
class 1: 0.30-0.99 | 13 (33.3) | 8 (20.5) | 13 (34.2) | |
class 2: 1.00-2.99 | 2 (5.2) | 11 (28.2) | 11 (28.9) | |
class 3: ≥3.00 | 0 (0) | 0 (0) | 3 (7.9) | |
sTWEAK (pg/ml, median, IQR) | 921.4 (828.8, 1089.1) | 957.1 (874.3, 1103.7) | 941.5 (836.4, 1124.6) | 0.95 |
Histopathologic mean ± SD (range) | ||||
Total glomerular number | 18.2 ± 7.9 (8–42) | 19.6 ± 7.5 (8–37) | 18.7 ± 8.0 (8–44) | 0.74 |
Global glomerular sclerosis (%) | 7.6 ± 11.0 (0–50.0) | 11.0 ± 13.5 (0–62.5) | 13.7 ± 13.3 (0–44.4) | 0.11 |
Mesangial hypercellularity score | 0.47 ± 0.29 (0.09-1.3) | 0.57 ± 0.30 (0.1-1.6) | 0.61 ± 0.25 (0.13-1.1) | 0.12 |
Endocapillary hypercellularity (%) | 3.0 ± 5.8 (0–26.7) | 1.6 ± 2.9 (0–13.3) | 3.7 ± 5.6 (0–20.0) | 0.15 |
Segmental glomerulosclerosis (%) | 4.0 ± 8.1 (0–40.0) | 5.5 ± 7.4 (0–37.5) | 6.6 ± 9.1 (0–33.3) | 0.37 |
Interstitial fibrosis (%) | 14.3 ± 5.7 (6.3-28.0) | 15.4 ± 5.6 (3.8-32.8) | 18.6 ± 7.1 (7.9-39.7) C | 0.01 |
Extracapillary proliferation (%) | 3.6 ± 6.6 (0–25.0) | 5.9 ± 7.5 (0–29.4) | 8.5 ± 8.9 (0–37.5) D | 0.02 |
Histological-grade I/II/III/IV (%)a | 69/28/0/3 | 59/33/8/0 | 34/44/16/5 | 0.03 |