Variability in estimated glomerular filtration rate values is a risk factor in chronic kidney disease progression among patients with diabetes

Table 1 Death and dialysis outcomes and baseline population characteristics

	Total population	(N = 70,598; 100%)	Early stage 3 CKD	(N = 43,228; 61.2%)	Late stage 3 CKD	(N = 20,387; 28.9%)	Stage 4 CKD	(N = 6,983; 9.9%)
	N	%	N	%	N	%	N	%
OUTCOMES
Dialysis	7,193	10.3	1,749	4	2,493	12.4	2,951	42.8
Dialysis-free death	19,939	28.3	10,844	25.1	6,957	34.4	2,138	30.5
CHARACTERISTICS
Age (in years)
<45	460	0.6	256	0.6	131	0.7	73	1
45-54	4502	6.4	2663	6.1	1218	6	621	8.9
55-64	11495	16.3	7275	16.9	3005	14.7	1215	17.3
65-74	29068	41.3	19374	45	7123	34.9	2571	37.5
75-84	23993	33.9	13108	30.2	8504	41.8	2381	33.6
85 and above	1080	1.5	552	1.3	406	2	122	1.8
Sex
Men	68818	97.5	42120	97.5	19889	97.6	6809	97.6
Women	1780	2.5	1108	2.5	498	2.4	174	2.4
Race
White	57713	81.9	35886	83.2	16625	81.6	5202	74.6
African American	10017	14.2	5687	13.2	2906	14.3	1424	20.5
Hispanic	1682	2.3	986	2.2	494	2.4	202	2.7
Others	1186	1.6	669	1.4	362	1.7	155	2.2
VHA priority status
Severely disabled	17013	24.1	9835	22.8	5116	24.9	2062	29.8
Moderately disabled	11469	16.2	7100	16.4	3348	16.3	1021	14.7
Poverty	33320	47.2	20749	48	9420	46.3	3151	44.7
Co-pay	7916	11.3	5009	11.6	2237	11.2	670	9.9
Missing	880	1.2	535	1.2	266	1.3	79	0.01
Prior hospitalizations
Yes	25820	36.6	14246	32.9	8276	40.5	3298	47.7
No	44778	63.4	28982	67.1	12111	59.5	3685	52.3
Cardiovascular conditions
Yes	49019	69.5	28666	66.2	15021	0.74	5332	76.9
No	21579	30.5	14562	33.8	5366	0.26	1651	23.1
Other physical conditions
Yes	69391	98.3	42372	98	20104	98.6	6915	99.2
No	1207	1.7	856	2	283	1.4	68	0.8
Mental comorbidities
Yes	13533	19	8467	19.5	3811	18.5	1255	17.8
No	57065	81	34761	80.5	16576	81.5	5728	82.2
Qualifying eGFR, mean ± sd (in ml/min/1.73 m2)	46 ± 11		53 ± 4		39 ± 4		24 ± 4
Age (in years)	70 ± 9		70 ± 9		71 ± 9		69 ± 10

Notes: Because of rounding, percentages may not be equal to 100.
CKD: Chronic Kidney Disease; VHA: Veterans Health Administration; eGFR: estimated Glomerular Filtration Rate; qualifying eGFR is the subsequent eGFR 90 to 365 days apart from the index eGFR; sd: standard deviation.

ISSN: 1471-2369