Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management

Table 2 ROS scavenging activities of uremic solutes, expressed as concentration needed for 50% inhibition (IC₅₀**± SEM*, μmol/L)**

Solutes	ABTS ^•+	O ₂^•-	H ₂ O ₂ ***	HOCl/OCl ⁻	Crocin bleaching assay
L-arginine	61,350.00 ± 562.56	**	**	92,100.00 ± 0.10	**
Creatinine	536.26 ± 3.32	**	**	9,130.00 ± 0.10	**
p -cresol	3.99 ± 0.01	**	**	15.75 ± 0.12	1,162.31
Hippuric acid	**	**	**	1,600.00 ± 0.01	**
Methylguanidine	**	**	**	**	**
Phenol	12.98 ± 0.09	**	**	8.95 ± 0.10	1,125.81
Trolox	16.45 ± 0.30	2,223.10 ± 0.17	**	8.65 ± 0.27	10.09
L-tyrosine	5.23 ± 0.02	**	**	2.83 ± 0.04	**
Urea	**	**	**	5,600.00 ± 0.20	**
Uric acid	16.75 ± 0.14	**	**	5.75 ± 0.13	6.90

Values in μmol/L of IC₅₀ of solutes; * SEM (standard error of the mean); ** No effect at the concentration used; *** Method was validated by reaction of H₂O₂ with catalase.

ISSN: 1471-2369