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Table 3 Comparison between competitive kinetic slopes and IC 50 , for the crocin bleaching assay

From: Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management

Solutes

Slope of regression line*

IC 50 (μmol/L)**

Uric acid

4.015

6.90

Trolox

2.230

10.09

Phenol

0.023

1,125.81

p -cresol

0.016

1,162.31

L-tyrosine

0.007

***

Methylguanidine

9.272x10−4

***

L-arginine

7.727x10−4

***

Hippuric acid

8.000x10−5

***

Creatinine

6.776x10−5

***

Urea

2.558x10−6

***

  1. *Regression line slopes in order of decreasing efficacy; **IC50 in order of decreasing efficacy, from plot of equation: % In = (1- (Δv/Δvo)) × 100; ***IC50> highest concentration tested.
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BMC Nephrology

ISSN: 1471-2369

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