Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management

Table 4 Relations between the IC ₅₀ of the solutes uric acid, phenol, p -cresol and L-tyrosine for their scavenging of: (A) ABTS ^•+ , (B) HOCl/OCl ⁻ and the IC ₅₀ of mixed samples

Uremic solutes in mixture	Volume (μL) of solute mixture needed for IC ₅₀	Concentration (μmol/L) of each solute in mixture at IC ₅₀	IC ₅₀ (μmol/L) of single solutes	Ratio of concentration of each solute in the IC ₅₀ of the mixture to its respective IC ₅₀ , for ABTS ^•+
A	ABTS ^•+	ABTS ^•+	ABTS ^•+	ABTS ^•+
p -cresol		1.06	3.99	0.26
L-tyrosine	39.85	1.39	5.23	0.26
Phenol		3.45	12.98	0.26
Uric acid		4.45	16.75	0.26
B	HOCl/OCl ⁻	HOCl/OCl ⁻	HOCl/OCl ⁻	HOCl/OCl ⁻
L-tyrosine		0.78	2.83	0.27
Uric acid	41.70	1.60	5.75	0.27
Phenol		2.50	8.95	0.27
p -cresol		4.38	15.75	0.27

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