PTH change group | ||||||
---|---|---|---|---|---|---|
Patient characteristics | No PTH reduction | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P |
n | 982 | 621 | 621 | 621 | 622 | |
Mean (SD) percent change in PTH | +38.5 (43.9) | −11.2 (6.1) | −31.8 (5.8) | −52.2 (6.1) | −78.2 (9.2) | NA |
Age, yrs. | ||||||
Mean (SD) | 57.8 (15.0) | 57.7 (14.7) | 59.2 (14.4) | 61.0 (14.1) | 62.6 (13.4) | <0.0001 |
18-44 | 20.7 | 21.1 | 17.4 | 13.7 | 10.0 | <0.0001 |
45-64 | 44.7 | 43.6 | 45.3 | 43.8 | 43.1 | |
65-74 | 20.7 | 22.1 | 23.8 | 25.3 | 28.1 | |
≥75 | 14.0 | 13.2 | 13.5 | 17.2 | 18.8 | |
Race | ||||||
African American | 53.1 | 51.9 | 49.6 | 50.6 | 48.9 | 0.48 |
White | 24.8 | 26.9 | 28.2 | 27.5 | 25.4 | |
Other | 22.2 | 21.3 | 22.2 | 21.9 | 25.7 | |
Male sex | 53.8 | 54.9 | 54.9 | 49.6 | 46.5 | 0.01 |
Dialysis duration, yrs., mean (SD) | 6.0 (4.6) | 5.8 (4.4) | 5.8 (4.1) | 5.4 (4.0) | 5.8 (4.4) | 0.3 |
BMI, kg/m2, mean (SD) | 27.5 (7.2) | 27.7 (6.9) | 27.9 (7.0) | 27.9 (7.2) | 27.1 (6.3) | 0.23 |
Intact PTH, pg/mL, pre-cinacalcet prescription | ||||||
Mean (SD) | 687 (387) | 798 (500) | 756 (454) | 739 (379) | 740 (386) | |
>300- ≤ 600 | 54.9 | 42.8 | 46.7 | 45.7 | 44.7 | <0.0001 |
>600 | 45.1 | 57.2 | 53.3 | 54.3 | 55.3 | |
Corrected calcium, mg/dL | ||||||
Mean (SD) | 9.83 (0.7) | 9.70 (0.7) | 9.70 (0.7) | 9.72 (0.7) | 9.64 (0.7) | |
<9.0 mg/dL | 11.0 | 14.7 | 11.1 | 10.6 | 13.7 | <0.0001 |
≥9.0- ≤ 10.2 | 60.2 | 62.3 | 68.4 | 69.2 | 70.6 | |
>10.2 | 28.8 | 23.0 | 20.5 | 20.1 | 15.8 | |
Phosphorus, mg/dL | ||||||
Mean (SD) | 6.4 (1.8) | 6.4 (1.6) | 6.1 (1.5) | 5.9 (1.5) | 5.9 (1.5) | <0.0001 |
<3.5 mg/dL | 2.6 | 1.5 | 2.3 | 3.4 | 1.9 | 0.0002 |
≥3.5– ≤ 5.0 | 19.7 | 19.5 | 22.5 | 25.1 | 28.8 | |
>5.0 | 77.8 | 79.1 | 75.2 | 71.5 | 69.3 | |
Kt/V, mean (SD) | 1.7 (0.4) | 1.7 (0.4) | 1.7 (0.5) | 1.7 (0.4) | 1.7 (0.4) | 0.85 |
Primary cause of ESRD | ||||||
Diabetes | 36.1 | 38.2 | 41.2 | 38.0 | 45.2 | 0.07 |
Hypertension | 34.6 | 33.2 | 31.1 | 34.6 | 31.2 | |
Glomerulonephritis | 13.2 | 11.9 | 13.5 | 11.0 | 10.6 | |
Other | 16.1 | 16.8 | 14.2 | 16.4 | 13.0 | |
Hospital days | ||||||
0 | 60.6 | 65.4 | 64.3 | 60.4 | 59.8 | 0.53 |
1-2 | 8.4 | 7.3 | 7.1 | 9.5 | 7.1 | |
3-5 | 10.5 | 9.5 | 9.2 | 10.3 | 11.7 | |
>5 | 20.6 | 17.9 | 19.5 | 19.8 | 21.4 | |
Phosphate binder use at first cinacalcet prescription | ||||||
Calcium containing | 41.0 | 40.6 | 39.6 | 40.4 | 44.1 | 0.56 |
Non-calcium containing | 81.3 | 80.4 | 80.8 | 79.6 | 77.0 | 0.30 |
Combination | 26.8 | 24.8 | 24.0 | 24.8 | 24.4 | 0.72 |
None | 4.5 | 3.9 | 3.5 | 4.8 | 3.4 | 0.62 |
Comorbidity | ||||||
ASHD | 26.0 | 24.2 | 27.5 | 32.4 | 28.8 | 0.01 |
CHF | 26.3 | 25.0 | 25.4 | 28.2 | 28.6 | 0.49 |
CVA/TIA | 9.2 | 8.9 | 8.4 | 9.7 | 9.5 | 0.94 |
PVD | 24.5 | 23.2 | 24.6 | 27.9 | 28.9 | 0.09 |
Other cardiac disease | 23.0 | 24.6 | 24.0 | 21.9 | 22.0 | 0.73 |
COPD | 11.4 | 11.6 | 11.1 | 11.9 | 12.7 | 0.92 |
GI disease | 5.5 | 4.2 | 5.2 | 6.6 | 6.6 | 0.29 |
Liver disease | 2.4 | 1.8 | 1.3 | 2.7 | 2.4 | 0.38 |
Dysrhythmia | 16.5 | 17.4 | 18.5 | 19.7 | 18.8 | 0.53 |
Cancer | 3.6 | 5.6 | 4.8 | 6.3 | 4.3 | 0.11 |
Diabetes | 47.9 | 50.9 | 53.0 | 53.1 | 55.7 | 0.03 |
Days from last PTH level to first cinacalcet prescription | 15.4 (13.5) | 14.2 (12.1) | 13.1 (10.9) | 14.3 (12.2) | 14.7 (12.6) | 0.01 |