Severe hypertriglyceridemia and hypercholesterolemia accelerating renal injury: a novel model of type 1 diabetic hamsters induced by short-term high-fat / high-cholesterol diet and low-dose streptozotocin

Table 3 Glu, TG and TC levels for each group 4 weeks after a high fat and /or high cholesterol diet

Group	N	B.W	Glu	TG	TC	Insulin
Group	N	(g)	(mmol/l)	(mmol/l)	(mmol/l)	(ng/ml)
C-C^a	6	111 ± 7	7.2 ± 1.3	1.4 ± 0.7	4.3 ± 0.6	1.58 ± 0.17
C-HF^a	6	141 ± 4	8.0 ± 1.5	1.6 ± 0.6	3.8 ± 0.5	1.55 ± 0.12
C-HC^a	6	115 ± 4	6.4 ± 0.6	1.6 ± 0.6	7.1 ± 0.6^**	1.56 ± 0.05
C-HFHC^a	6	139 ± 4	9.0 ± 0.9	7.8 ± 3.3^**	26.6 ± 11.4^**	1.59 ± 0.07
D-C^b	6	98 ± 16^*	20.1 ± 5.8^***	1.8 ± 0.7	4.3 ± 1.1	1.12 ± 0.05^**
D-HF^b	6	97 ± 11^***	21.7 ± 6.5^***	6.1 ± 3.1^**##	8.3 ± 4.5^*#	1.18 ± 0.14^**
D-HC^b	6	94 ± 1^**	19.6 ± 1.7^***	3.8 ± 1.1^**##	30.8 ± 9.5^**##	1.18 ± 0.06^***
D-HFHC^b	6	100 ± 8^***	16.3 ± 3.9^***	116.7 ± 69.2^***###	75.8 ± 49.5^***###	1.17 ± 0.07^***

^a non-diabetic hamsters; ^b diabetic hamsters.
^***P<0.001, ^**P<0.01, ^*P<0.05 vs non-diabetic counterparts(C-C,C-HF,C-HC and C-HFHC).
^### P<0.001, ^## P<0.01, ^# P<0.05 vs D-C group.

ISSN: 1471-2369