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Table 3 Adverse events

From: Trace element supplementation in hemodialysis patients: a randomized controlled trial

 

Medium dose

Low dose

Medium and low dose combined

Standard dose

Exact P-value

Non-serious events

7 (13.7)

3 (6.4)

10 (10.2)

7 (14.3)

0.59

Self-reported tremor

0 (0)

1 (2.1)

1 (1.0)

0 (0)

<0.99

Color and texture of fingernails

3 (5.9)

1 (2.1)

4 (4.1)

2 (4.1)

<0.99

Frequent vomiting

0 (0)

1 (2.1)

1 (1.0)

2 (4.1)

0.26

Severe neutropenia

3 (5.9)

0 (0)

3 (3.1)

3 (6.1)

0.40

Severe anemia

1 (2.0)

0 (0)

1 (1.0)

0 (0)

<0.99

Low copper status

23 (50.0)

22 (47.8)

45 (48.9)

27 (58.7)

0.28

Serious events

     

Death

0 (0)

4 (8.5)

4 (4.1)

2 (3.9)

0.65

Hospitalization1

8 (15.4)

9 (19.2)

17 (17.2)

7 (13.7)

0.79

Hospitalizations

9

12

21

8

 
  1. Counts (percentages) are reported. P-values statistically compare the combined dose group to the standard group. Bolded values are significantly different from the standard group. Low copper status <1061 ug/L.
  2. 15 participants (3 in the low dose group and 1 in the standard dose group and 1 in the medium dose group) had 2 SAE-specific hospitalizations. In the above analysis, only 1 hospitalization is counted per participant (rather than per SAE-specific event).