Pharmacokinetics of nalbuphine hydrochloride extended release tablets in hemodialysis patients with exploratory effect on pruritus

Table 3 Statistical analysis of the effects of hemodialysis on the pharmacokinetics of nalbuphine

Parameter	Dose (mg)	N ^a	Geometric means		Statistics
Parameter	Dose (mg)	N ^a	On dialysis (test, T)	Non-dialysis (reference, R)	GMR (T/R)	90% Confidence limit
AUC_tau (ng•h/mL)	30	11/14	86.46	94.14	91.85	81.02, 104.12
	60	10/10	188.59	159.84	117.99	103.56, 134.43
	120	10/10	418.26	442.56	94.51	83.46, 107.03
	180	13/9	567.05	599.15	94.64	82.95, 107.99
C_max (ng/mL)	All doses	15/14	31.04	31.39	98.90	89.73, 109.01

^aNumber of patients on dialysis/non-dialysis days.
Abbreviations: AUC_tau area under the plasma concentration-time curve over the dosing interval, CI confidence interval, C_max maximum observed plasma concentration, h hour, GMR geometric mean ratio.

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