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Figure 1 | BMC Nephrology

Figure 1

From: Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation

Figure 1

Kidney-specific knockout of Dgcr8 results in end stage renal disease. A Conditional Dgcr8 fl/fl; KspCre knockout mice are markedly smaller than their control littermates (7 week old animals) BDgcr8 knockout mice have a significant lower body weight in comparison to their control littermates (4 week old animals; * = p < 0.05; error bars represent SEM; knockout: n = 3; control: n = 5) CDgcr8 knockout mice develop end stage renal disease as displayed by elevated serum urea levels in comparison to control animals (4–7 week old animals; *** = p < 0.001; error bars represent SEM; knockout: n = 6; control: n = 13).

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