Figure 3

Hydronephrosis and cystic kidneys of Dgcr8 knockout animals. A Conditional knockout of Dgcr8 in the renal tubulus system leads to hydronephrosis. B + C Histological analysis confirms hydronephrosis with severe loss of kidney parenchyma especially in the medulla region, a thinned cortex and kidney cysts (bar = 1000 μm (B) and 200 μm (C)).