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Table 1 Baseline characteristics of SHARP patients included in the cost analysis

From: What is the impact of chronic kidney disease stage and cardiovascular disease on the annual cost of hospital care in moderate-to-severe kidney disease?

  By baseline CKD stage 1 Overall
  CKD 1-3B (eGFR: ≥30) 2 CKD 4 (eGFR: ≥15, <30) CKD 5 (eGFR: <15 not on dialysis) On dialysis  
Number of patients 1,494 2,228 1,017 2,498 7,246
Men 1,078 (72%) 1,368 (61%) 599 (59%) 1,600 (64%) 4,652 (64%)
Age (years) 62 (11) 65 (12) 63 (12) 61 (12) 63 (12)
Prior vascular disease 189 (13%) 350 (16%) 147 (14%) 428 (17%) 1,116 (15%)
Prior diabetes mellitus 268 (18%) 454 (20%) 169 (17%) 546 (22%) 1,439 (20%)
Current smoker 205 (14%) 276 (12%) 133 (13%) 432 (17%) 1,048 (14%)
Body-mass index (kg/m2) 28.4 (5.3) 28.2 (5.8) 27.5 (5.5) 27.0 (5.9) 27.8 (5.7)
Diastolic blood pressure (mm Hg) 80 (13) 79 (13) 80 (12) 77 (13) 79 (13)
Systolic blood pressure (mm Hg) 138 (20) 138 (20) 141 (20) 137 (24) 138 (21)
Total cholesterol (mmol/L) 5.1 (1.1) 5.1 (1.1) 4.9 (1.2) 4.6 (1.2) 4.9 (1.2)
LDL cholesterol (mmol/L) 3.0 (0.8) 2.9 (0.8) 2.8 (0.9) 2.6 (0.9) 2.8 (0.9)
HDL cholesterol (mmol/L) 1.2 (0.3) 1.2 (0.3) 1.1 (0.3) 1.1 (0.4) 1.1 (0.3)
Triglycerides (mmol/L) 2.3 (1.6) 2.3 (1.4) 2.2 (1.4) 2.3 (1.9) 2.3 (1.6)
Renal status      
 On dialysis - - - 2,498 (100%) 2,498 (34%)
  Hemodialysis - - - 2,076 (83%) 2,076 (29%)
  Peritoneal dialysis - - - 422 (17%) 422 (6%)
 Not on dialysis 1,494 (100%) 2,228 (100%) 1,017 (100%) - 4,739 (65%)
Estimated glomerular filtration rate (mL/min/1.732) 37.6 (6.5) 22.5 (4.3) 10.8 (2.7) - 24.8 (10.9)
Urinary albumin:creatinine ratio (mg/g)3      
 Median (IQR) 75 (16–328) 155 (36–592) 397 (124–1,204) - 156 (35–626)
 <30 459 (36%) 426 (22%) 62 (7%) - 947 (23%)
 ≥30, ≤ 300 496 (38%) 820 (42%) 332 (37%) - 1,648 (40%)
 >300 336 (26%) 722 (37%) 511 (56%) - 1,569 (38%)
 Not available 203 260 112 - 584
Region of recruitment      
 Europe 1,022 (68%) 1,546 (69%) 730 (72%) 1,779 (71%) 5,083 (70%)
 Australasia 260 (17%) 446 (20%) 187 (18%) 408 (16%) 1,302 (18%)
 North America 212 (14%) 236 (11%) 100 (10%) 311 (12%) 861 (12%)
  1. Data are n (%), mean (SD) or median (IQR); CKD = chronic kidney disease.
  2. 19 patients who received a transplant prior to randomization were excluded from the tabulation by baseline CKD stage.
  3. 2Predominantly CKD stage 3B (eGFR ≥30 to <45 ml/min/1.73m2).
  4. 3Percentages exclude patients for whom data were not available.