By baseline CKD stage 1 | Overall | ||||
---|---|---|---|---|---|
CKD 1-3B (eGFR: ≥30) 2 | CKD 4 (eGFR: ≥15, <30) | CKD 5 (eGFR: <15 not on dialysis) | On dialysis | ||
Number of patients | 1,494 | 2,228 | 1,017 | 2,498 | 7,246 |
Men | 1,078 (72%) | 1,368 (61%) | 599 (59%) | 1,600 (64%) | 4,652 (64%) |
Age (years) | 62 (11) | 65 (12) | 63 (12) | 61 (12) | 63 (12) |
Prior vascular disease | 189 (13%) | 350 (16%) | 147 (14%) | 428 (17%) | 1,116 (15%) |
Prior diabetes mellitus | 268 (18%) | 454 (20%) | 169 (17%) | 546 (22%) | 1,439 (20%) |
Current smoker | 205 (14%) | 276 (12%) | 133 (13%) | 432 (17%) | 1,048 (14%) |
Body-mass index (kg/m2) | 28.4 (5.3) | 28.2 (5.8) | 27.5 (5.5) | 27.0 (5.9) | 27.8 (5.7) |
Diastolic blood pressure (mm Hg) | 80 (13) | 79 (13) | 80 (12) | 77 (13) | 79 (13) |
Systolic blood pressure (mm Hg) | 138 (20) | 138 (20) | 141 (20) | 137 (24) | 138 (21) |
Total cholesterol (mmol/L) | 5.1 (1.1) | 5.1 (1.1) | 4.9 (1.2) | 4.6 (1.2) | 4.9 (1.2) |
LDL cholesterol (mmol/L) | 3.0 (0.8) | 2.9 (0.8) | 2.8 (0.9) | 2.6 (0.9) | 2.8 (0.9) |
HDL cholesterol (mmol/L) | 1.2 (0.3) | 1.2 (0.3) | 1.1 (0.3) | 1.1 (0.4) | 1.1 (0.3) |
Triglycerides (mmol/L) | 2.3 (1.6) | 2.3 (1.4) | 2.2 (1.4) | 2.3 (1.9) | 2.3 (1.6) |
Renal status | |||||
On dialysis | - | - | - | 2,498 (100%) | 2,498 (34%) |
Hemodialysis | - | - | - | 2,076 (83%) | 2,076 (29%) |
Peritoneal dialysis | - | - | - | 422 (17%) | 422 (6%) |
Not on dialysis | 1,494 (100%) | 2,228 (100%) | 1,017 (100%) | - | 4,739 (65%) |
Estimated glomerular filtration rate (mL/min/1.732) | 37.6 (6.5) | 22.5 (4.3) | 10.8 (2.7) | - | 24.8 (10.9) |
Urinary albumin:creatinine ratio (mg/g)3 | |||||
Median (IQR) | 75 (16–328) | 155 (36–592) | 397 (124–1,204) | - | 156 (35–626) |
<30 | 459 (36%) | 426 (22%) | 62 (7%) | - | 947 (23%) |
≥30, ≤ 300 | 496 (38%) | 820 (42%) | 332 (37%) | - | 1,648 (40%) |
>300 | 336 (26%) | 722 (37%) | 511 (56%) | - | 1,569 (38%) |
Not available | 203 | 260 | 112 | - | 584 |
Region of recruitment | |||||
Europe | 1,022 (68%) | 1,546 (69%) | 730 (72%) | 1,779 (71%) | 5,083 (70%) |
Australasia | 260 (17%) | 446 (20%) | 187 (18%) | 408 (16%) | 1,302 (18%) |
North America | 212 (14%) | 236 (11%) | 100 (10%) | 311 (12%) | 861 (12%) |