What is the impact of chronic kidney disease stage and cardiovascular disease on the annual cost of hospital care in moderate-to-severe kidney disease?

Table 2 Number of patient years with events and use of renal replacement therapy by baseline CKD stage

	Baseline CKD stage ¹				Overall
	CKD 1-3B ²	CKD 4	CKD 5 not on dialysis	On dialysis
Number of patients	1,494	2,228	1,017	2,498	7,246
Vascular death	36 (0.6%)	92 (1.0%)	86 (2.2%)	235 (2.5%)	449 (1.6%)
Non-vascular death	97 (1.6%)	219 (2.5%)	151 (3.8%)	453 (4.9%)	920 (3.3%)
Non-fatal major vascular event in the current annual period	93 (1.5%)	222 (2.5%)	128 (3.2%)	385 (4.1%)	828 (2.9%)
Kidney transplantation in the current annual period	14 (0.2%)	142 (1.6%)	213 (5.4%)	625 (6.7%)	994 (3.5%)
On functioning kidney transplant from an earlier annual period	9 (0.1%)	126 (1.4%)	335 (8.5%)	1,170 (12.5%)	1,663 (5.9%)
Dialysis initiated during the current annual period	77 (1.3%)	548 (6.2%)	718 (18.2%)	18 (0.2%)	1,362 (4.8%)
On dialysis since an earlier annual period	44 (0.7%)	609 (6.9%)	1,337 (33.8%)	7,526 (80.6%)	9,516 (33.7%)

Data are the number of annual periods in which the defined event occurs or the RRT status, and percentage of all annual periods. In each annual period, each participant on renal replacement therapy is classified into one of: (1) kidney transplantation in current annual period; (2) functioning kidney transplantation from an earlier annual period; (3) dialysis initiated during the current annual period; and (4) on dialysis since an earlier annual period.
CKD = chronic kidney disease.
¹9 patients who received a transplant prior to randomization were excluded from the tabulation by baseline CKD stage.
²Predominantly CKD stage 3B (eGFR ≥30 to <45 ml/min/1.73m²).

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