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Table 4 Sensitivity analysis

From: Cystatin C and long term risk of community-acquired sepsis: a population-based cohort study

Variable

Unadjusted

Model 1

Model 2

Model 3

Model 4

Model 5

Cystatin C ā‰„1.12 mg/dL

2.70 (2.43-3.00)

1.51 (1.32-1.72)

Ā 

1.60 (1.40-1.83)

Ā Ā 

Cystatin C Quartiles

Ā Ā Ā Ā Ā Ā 

Q1 (<0.83 mg/dL)

Ref

Ā 

Ref

Ā 

Ref

Ā 

Q2 (0.83-0.94 mg/dL)

1.40 (1.16-1.69)

Ā 

1.14 (0.94-1.37)

Ā 

1.14 (0.94-1.38)

Ā 

Q3 (0.95-1.12 mg/dL)

1.81 (1.51-2.17)

Ā 

1.20 (0.96-1.45)

Ā 

1.22 (1.01-1.47)

Ā 

Q4 (>1.12 mg/dL)

3.77 (3.20-4.45)

Ā 

1.72 (1.42-2.09)

Ā 

1.85 (1.51-2.27)

Ā 

Cystatin C (per SD) (mg/dL)

1.24 (1.21-1.27)

Ā Ā Ā Ā 

1.16 (1.11-1.21)

eGFR <60 ml/min/1.73m2

2.38 (2.10-2.70)

1.14 (0.98-1.32)

1.14 (0.98-1.32)

Ā Ā Ā 

ACR ā‰„30 mg/g

2.22 (1.97-2.49)

1.45 (1.28-1.65)

1.45 (1.28-1.65)

Ā Ā Ā 

hsCRP >3.0 mg/dL

1.71 (1.54-1.90)

1.48 (1.32-1.65)

1.47 (1.31-1.64)

Ā Ā Ā 

eGFR <73.1 ml/min/1.73m2

1.91 (1.72-2.12)

Ā Ā 

1.00 (0.87-1.14)

0.98 (0.86-1.12)

Ā 

ACR ā‰„16.1 mg/g

2.05 (1.85-2.28)

Ā Ā 

1.41 (1.26-1.58)

1.41 (1.26-1.58)

Ā 

hsCRP >5.0 mg/dL

1.75 (1.57-1.95)

Ā Ā 

1.51 (1.34-1.69)

1.49 (1.33-1.68)

Ā 

eGFR (per SD) (ml/min/1.73m2)

0.69 (0.65-0.72)

Ā Ā Ā Ā 

0.97 (0.90-1.04)

ACR (per SD) (mg/g)

1.07 (1.03-1.11)

Ā Ā Ā Ā 

1.01 (0.97-1.06)

hsCRP (per SD) (mg/dL)

1.12 (1.10-1.15)

Ā Ā Ā Ā 

1.10 (1.06-1.14)

  1. Hazard ratios (HRs) and 95% confidence intervals (CI) for the associations between Cystatin-C levels and rates of sepsis.
  2. Estimates pooled after multiple imputation using Rubinā€™s rules. Total of 29,696 REGARDS participants included in the analysis. Except for unadjusted model, all models adjusted for sociodemographics, health behaviors, and chronic medical conditions. eGFR = estimated glomerular filtration rate. ACR = albumin-to-creatinine ratio. hsCRP = high sensitivity C-reactive protein. Cyst-C levels ranged from 0.1 to 11.9 mg/dL.
  3. Model 1 ā€“ Primary model; binary Cyst-C; binary eGFR, ACR and hsCRP using clinical cutpoints.
  4. Model 2 ā€“ Cyst-C quartiles; binary eGFR, ACR and hsCRP using clinical cutpoints.
  5. Model 3 ā€“ Binary Cyst-C; binary eGFR, ACR and hsCRP using 75th percentile as cutpoints.
  6. Model 4 ā€“ Cyst-C quartiles; binary eGFR, ACR and hsCRP using 75th percentile as cutpoints.
  7. Model 5 ā€“ Continuous Cyst-C, eGFR, ACR and hsCRP, normalized by standard deviation.