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Table 2 Medians and inter-quartile range of inflammatory biomarkers according to chronic kidney disease status

From: Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease

Inflammatory Biomarkers

Unadjusted median (IQR)

Multivariable-adjusted median (IQR)a

CKD patients (n = 201)

Non-CKD controls (n = 201)

P-value for difference

CKD patients (n = 201)

Non-CKD controls (n = 201)

P-value for difference

CRP, mg/L (IQR)

2.80 (1.13, 5.61)

1.49 (0.75, 3.65)

<0.0001

2.91 (1.47, 5.24)

1.91 (0.99, 3.79)

0.39

TNF-α, pg/mL (IQR)

1.82 (1.5, 2.51)

1.27 (0.99, 1.81)

<0.0001

1.86 (1.51, 2.63)

1.26 (1.01, 1.98)

<0.0001

IL-6, pg/mL (IQR)

2.46 (1.32, 4.54)

1.24 (0.88, 2.2)

<0.0001

2.53 (1.49, 4.42)

1.39 (0.95, 2.15)

0.04

  1. IQR = inter-quartile range; CRP = C-reactive protein; TNF-α = tumor necrosis factor alpha; IL-6 = interleukin 6
  2. aAdjusted for age, gender, race, high-school education, physical activity, current cigarette smoking, weekly alcohol drinking, body-mass index, LDL-cholesterol, plasma glucose, systolic blood pressure, history of cardiovascular disease, antihypertensive treatment, antidiabetic treatment, lipid lowering treatment, and aspirin use