Skip to main content

Table 3 Odds ratios of chronic kidney disease associated with the higher tertile compared to the lowest tertiles of inflammatory biomarkers

From: Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease

  Age, gender, and race-adjusted Multivariable-adjusteda
OR (95 % CI) P-value for trend OR (95 % CI) P-value for trend
CRP ( mg/L)     
≤1.1 1.0 (ref) 0.0002 1.0 (ref) 0.15
>1.1-3.3 1.3 (0.8-2.2) 1.2 (0.6-2.5)
>3.3 2.7 (1.6-4.1) 1.8 (0.8-3.9)
TNF-α (ng/mL)     
≤1.3 1.0 (ref) <0.0001 1.0 (ref) <0.0001
>1.3-1.9 6.6 (3.7-11.7) 5.8 (2.7-12.7)
>1.9 7.8 (4.4-13.8) 7.1 (3.2-15.5)
IL-6 (μg/mL)     
≤1.2 1.0 (ref) <0.0001 1.0 (ref) 0.02
>1.2-2.6 1.7 (1-2.8) 1.1 (0.5-2.3)
>2.6 5.0 (2.8-8.6)   2.5 (1.1-5.5)  
  1. CI confidence interval; CRP C-reactive protein; TNF-α tumor necrosis factor alpha; IL-6 interleukin 6
  2. aAdjusted for age, gender, race, high-school education, physical activity, current cigarette smoking, weekly alcohol drinking, body-mass index, LDL-cholesterol, plasma glucose, systolic blood pressure, history of cardiovascular disease, antihypertensive treatment, antidiabetic treatment, lipid lowering treatment, and aspirin use