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Table 3 Odds ratios of chronic kidney disease associated with the higher tertile compared to the lowest tertiles of inflammatory biomarkers

From: Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease

 

Age, gender, and race-adjusted

Multivariable-adjusteda

OR (95 % CI)

P-value for trend

OR (95 % CI)

P-value for trend

CRP ( mg/L)

    

≤1.1

1.0 (ref)

0.0002

1.0 (ref)

0.15

>1.1-3.3

1.3 (0.8-2.2)

1.2 (0.6-2.5)

>3.3

2.7 (1.6-4.1)

1.8 (0.8-3.9)

TNF-α (ng/mL)

    

≤1.3

1.0 (ref)

<0.0001

1.0 (ref)

<0.0001

>1.3-1.9

6.6 (3.7-11.7)

5.8 (2.7-12.7)

>1.9

7.8 (4.4-13.8)

7.1 (3.2-15.5)

IL-6 (μg/mL)

    

≤1.2

1.0 (ref)

<0.0001

1.0 (ref)

0.02

>1.2-2.6

1.7 (1-2.8)

1.1 (0.5-2.3)

>2.6

5.0 (2.8-8.6)

 

2.5 (1.1-5.5)

 
  1. CI confidence interval; CRP C-reactive protein; TNF-α tumor necrosis factor alpha; IL-6 interleukin 6
  2. aAdjusted for age, gender, race, high-school education, physical activity, current cigarette smoking, weekly alcohol drinking, body-mass index, LDL-cholesterol, plasma glucose, systolic blood pressure, history of cardiovascular disease, antihypertensive treatment, antidiabetic treatment, lipid lowering treatment, and aspirin use