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Table 4 Multivariable-adjusted regression coefficients (95 % confidence intervals) of estimated-glomerular filtration rate and urinary albumin associated with a one standard deviation difference in inflammatory biomarkers

From: Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease

Inflammatory biomarkers (SD) Estimated-glomerular filtration rate, mL/min/1.73 m2 Log (urinary albumin, mg/24-h)
β (95 % CI) P-value β (95 % CI) P-value
CRP (Log,1.33 mg/L) −1.27 (−4.11 to 1.58) 0.38 0.11 (−0.08 to 0.29) 0.27
TNF-α (Log,0.69 ng/mL) −5.02 (−7.56 to −2.47) 0.0001 0.27 (0.1 to 0.44) 0.002
IL-6 ( Log, 0.9 ng/mL) −4.69 (−7.65 to −1.73) 0.0028 0.35 (0.16 to 0.54) 0.0003
  1. Adjusted for age, gender, race, high-school education, physical activity, current cigarette smoking, weekly alcohol drinking, body mass index, LDL-cholesterol, plasma glucose, systolic blood pressure, history of cardiovascular disease, antihypertensive treatment, antidiabetic treatment, lipid lowering treatment, and aspirin use
  2. SD standard deviation; log log-transformation; CI confidence interval; CRP C-reactive protein; TNF-α tumor necrosis factor alpha; IL-6 interleukin 6