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Table 3 Baseline clinical characteristics of participants

From: Increased urinary Angiotensinogen/Creatinine (AGT/Cr) ratio may be associated with reduced renal function in autosomal dominant polycystic kidney disease patients

Parameters

Patients (N = 233)

Patients with htTKV (N = 189)

Patients without htTKV (N = 44)

P-value

Age (yr)

43.3 ± 9.7

43.8 ± 9.3

41.2 ± 11.3

0.198

Female

126 (54.1 %)

99 (52.4 %)

27 (61.4 %)

0.316

Age at diagnosis (yr)

34.7 ± 9.2

35.2 ± 9.2

32.2 ± 8.9

0.114

Hypertension

217 (93.1 %)

147 (77.8 %)

29 (65.9 %)

0.119

Duration of hypertension (yr)

8.6 ± 6.0

8.6 ± 5.9

8.6 ± 6.6

0.67

Systolic BP (mmHg)

129.8 ± 13.5

130.0 ± 13.8

129.0 ± 12.6

0.404

Diastolic BP (mmHg)

80.0 ± 9.9

80.5 ± 10.0

78.1 ± 9.4

0.049

Number of BP medication

1 (Min. 0, Max. 7)

1 (Min. 0, Max. 7)

1 (Min. 0, Max. 4)

0.686

ARB or ACEi medication (%)

153 (65.7 %)

122 (64.6 %)

30 (68.2 %)

0.825

HtTKV (mL/m)

-

705 (Min 119, Max. 3436)

-

-

Time gap between enrollment and CT volumetry (mo)

-

4.7 ± 4.0

-

-

Hemoglobin (g/dL)

13.4 ± 1.5

13.4 ± 1.6

13.3 ± 1.3

0.592

Creatinine (mg/dL)

1.1 ± 0.5

1.2 ± 0.5

0.9 ± 0.3

0.003

CKD-EPI eGFR (mL/min/1.73 m2)

80.5 ± 27.1

77.9 ± 27.1

91.7 ± 24.9

0.002

Random urine microalbumin-to-creatinine ratio (mg/g)

21.0 (9.0–64.5)

23.0 (11.0–66.5)

15.0 (6.0–43.0)

0.076

PRA (ng/mL/hr)

3.6 (1.4–8.2)

3.9 (1.4–9.0)

3.0 (0.9–5.3)

0.067

Plasma aldosterone (ng/dL)

15.8 (11.7–21.6)

14.9 (11.4–21.1)

18.3 (12.3–23.7)

0.232

Urinary AGT/Cr (μg/g)

13.7 (7.5–35.1)

14.9 (7.8–36.0)

13.1 (6.2–30.8)

0.289

Urinary NAG/Cr (IU/g)

3.9 (2.7–5.9)

4.0 (2.9–5.9)

3.5 (2.3–6.1)

0.206

Urinary β2MG/Cr (μg/g)

310.6 (214.3–560.0)

305.8 (215.9–552.9)

329.1 (206.3–654.6)

0.871

  1. Data are expressed as numbers (percentages), mean ± SD, or median (Interquartile range). HtTKV was measured in 189 patients with available height and CT volumetry. ACEi angiotensin converting enzyme inhibitor, AGT angiotensinogen, ARB angiotensin receptor blocker, β2MG β2-microglobulin, BP blood pressure, CKD-EPI eGFR chronic kidney disease epidemiology estimated glomerular filtration rate, HtTKV height-adjusted total kidney volume, PRA plasma renin activity, NAG N-acetyl-β-D-glucosaminidase. Urinary concentrations of biomarkers were log-transformed to fulfill the requirement of normal distribution of residuals