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Table 4 Linear regression analysis for risk factors for decreased estimated glomerular filtration rate

From: Increased urinary Angiotensinogen/Creatinine (AGT/Cr) ratio may be associated with reduced renal function in autosomal dominant polycystic kidney disease patients

Parameters

Univariable

Multivariable

B (95 % CI)

P value

B (95 % CI)

P value

Age (yr)

-1.14 (-1.3 to -0.9)

<0.001

-0.5 (-0.66 to -0.33)

<0.001

Gender

1.97 (-4.4 to 8.3)

0.54

  

Hypertension

-21.1 (-28.1 to -14.1)

<0.001

  

Initial eGFR (mL/min/1.73 m2)

0.67 (0.6 to 0.7)

<0.001

0.3 (0.22 to 0.38)

<0.001

Hemoglobin (g/dL)

6.86 (5.1 to 8.6)

<0.001

2.91 (1.61 to 4.21)

<0.001

Uric acid (mg/dL)

-8.84 (-10.7 to -6.95)

<0.001

-4.22 (-5.66 to -2.78)

<0.001

HtTKV (mL/m)

-18.8 (-22.6 to -15.0)

<0.001

-5.6 (-8.57 to -2.63)

<0.001

Albumin/Cr (mg/g)

-11.2 (-13.3 to -9.12)

<0.001

-3.31 (-4.99 to -1.64)

<0.001

Urinary AGT/Cr (μg/g)

-9.5 (-11.8 to -7.19)

<0.001

-1.63 (-3.74 to 0.48)

0.1

  1. In multivariate analysis, data were adjusted for age, hypertension, initial eGFR, plasma hemoglobin, serum uric acid, htTKV, random urine albumin-to-creatinine ratio, and urinary AGT/Cr by stepwise selection method. HtTKV, albumin/Cr, and AGT/Cr were log-transformed to fulfill the requirement of normal distribution of residuals. AGT angiotensinogen, Cr creatinine, eGFR estimated glomerular filtration rate, htTKV height-adjusted total kidney volume
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BMC Nephrology

ISSN: 1471-2369

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