| Â | Â | AGT | AngII | Ang-(1-7) | ACE | ACE2 | Chymase |
|---|
Normal | PT | ± | + | ++ | +++ | ++ | + |
DT | - | + | + | - | ++ | + |
Case I (ADPKD-CKD) | C | ++(diffuse) | ++ | ++ | - | ± | - |
PT | +++(diffuse) | ++ | +++ | + | ++++ | +++ |
DT | - | ++ | +++ | - | ++ | ++ |
Case II (ADPKD-ESRD) | C | ++(patchy) | ± | +++ | - | + | + |
PT | +++(patchy) | ± | +++ | ± | ++++ | +++ |
DT | - | ± | +++ | - | ++ | ++ |
- Normal kidney was obtained from 38-year-old male who underwent nephrectomy for renal cell carcinoma. His sCr level was 1.1 mg/dL at the time of operation. The polycystic kidney tissues were obtained from two patients. One patient underwent nephrectomy for renal cell carcinoma and her sCr level was 0.98 mg/dL. The other kidney tissue was obtained from end-stage renal disease patient who was preparing transplantation. ACE angiotensin-converting enzyme, ACE2 angiotensin-converting enzyme 2, AGT angiotensinogen, AngII angiotensin II, Ang-(1-7) angiotensin (1-7), C cyst-lining epithelial cells, DT distal tubules, ADPKD-CKD polycystic kidney disease – chronic kidney disease stage, ADPKD-ESRD polycystic kidney disease – end-stage renal disease stage, PT Proximal tubule
