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Table 3 Discrimination and calibration statistics for chronic kidney diseases risk model performance in subgroups of participants by gender, age and body mass index (BMI); for the outcome of CKD based on MDRD equation predicted glomerular filtration rate with or without proteinuria

From: Validation of two prediction models of undiagnosed chronic kidney disease in mixed-ancestry South Africans

Models (outcome)

 

Men

Women

Age < 60 years

Age ≥ 60 years

BMI < 25 kg/m2

BMI ≥ 25 kg/m2

Thai model (eGFR < 60 ml/min/1.73 m2)

E/O (95 % CI)

1.49 (1.10-2.02)

0.88 (0.77-1.00)

1.13 (0.90-1.42)

0.91 (0.79-1.05)

0.98 (0.76-1.26)

0.98 (0.85-1.12)

Brier score

0.127

0.177

0.121

0.238

0.128

0.180

Yates slope

0.267

0.190

0.0.032

0.083

0.259

0.175

C-statistic (95 % CI)

0.834 (0.770-0.899)

0.752 (0.714-0.790)

0.608 (0.550-0.666)

0.626 (0.567-0.685

0.854 (0.802-0.906)

0.723 (0.681-0.765)

Korean model (eGFR < 60 ml/min/1.73 m2)

E/O (95 % CI)

0.99 (0.73-1.34)

0.72 (0.63-0.82)

0.68 (0.54-0.85)

0.80 (0.69-0.92)

0.75 (0.59-0.97)

0.76 (0.66-0.88)

Brier score

0.112

0.179

0.116

0.243

0.129

0.177

Yates slope

0.246

0.199

0.049

0.087

0.259

0.186

C-statistic (95 % CI)

0.856 (0.792-0.920)

0.784 (0.747-0.821)

0.678 (0.615-0.741)

0.668 (0.610-0.726)

0.869 (0.814-0.923)

0.766 (0.727-0.806)

Thai model (eGFR < 60 ml/min/1.73 m2 or proteinuria)

E/O (95 % CI)

1.53 (1.13-2.08)

0.87 (0.76-0.99)

1.15 (0.92-1.43)

0.89 (0.78-1.03)

0.96 (0.75-1.23)

0.97 (0.85-1.12)

Brier score

0.127

0.175

0.123

0.233

0.125

0.179

Yates slope

0.267

0.205

0.040

0.092

0.276

0.184

C-statistic (95 % CI)

0.834 (0.770-0.899)

0.768 (0.732-0.805)

0.619 (0.561-0.676)

0.646 (0.587-0.704)

0.870 (0.821-0.919)

0.734 (0.693-0.775)

Korean mdel (eGFR < 60 ml/min/1.73 m2 or proteinuria)

E/O (95 % CI)

1.02 (0.75-1.38)

0.71 (0.62-0.80)

0.69 (0.55-0.86)

0.78 (0.68-0.91)

0.74 (0.58-0.95)

0.76 (0.66-0.87)

Brier score

0.112

0.176

0.116

0.235

0.125

0.175

Yates slope

0.246

0.219

0.059

0.104

0.284

0.201

C-statistic (95 % CI)

0.856 (0.792-0.920)

0.801 (0.766-0.836)

0.689 (0.626-0.751)

0.696 (0.640-0.753)

0.886 (0.834-0.937)

0.778 (0.740-0.817)

  1. eGFR, estimated glomerular filtration rate; E/O, Expected/Observed event rate; 95 % CI: 95 % confidence interval