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Table 6 Cross sectional analysis of total cholesterol tertiles and select metabolites

From: Cross-sectional examination of metabolites and metabolic phenotypes in uremia

  1 2 3 P
tryptophan 440 068 (345 130, 586637) 323192 (257580, 429806) 274624 (223120, 324798) 1.7E-9*
18:2 carnitine 60 494 (38 250, 107 981) 49 737 (27 163, 73 344) 32 084 (19 167, 53 863) 9.0E-7*
18:1 carnitine 88 418 (58 090, 144 102) 69 442 (40 568, 103 682) 47 134 (33 127, 74 763) 6.0E-7*
18:0 carnitine 12 789 (10 118, 18 240) 10 879 (7 872, 14 622) 8 466 (6 103, 12 433) 7.7E-5*
arginine 175 576 (136 362, 259 524) 187 566 (132 389, 324 585) 321 420 (216 851, 491 848) 9.6E-6*
10:0 carnitine 52 498 (28 731, 92 694) 40 556 (26 190, 67 085) 34 244 (20 094, 52 420) 7.0E-3
glycocholate 193 580 (60 425, 672 001) 105 938 (61 765, 208 013) 76 985 (42 135, 222 324) 5.6E-3
taurocholate 128 124 (30 180, 379 765) 91 894 (35 067, 188 948) 47 535 (24 706, 128 025) 1.9E-2
GMP 640 409 (341 616, 884 723) 544 860 (409 493, 969 998) 831 864 (565 936, 1 246 583) 8.9E-3
AMP 2 898 935 (2 275 762, 3 795 325) 3 153 490 (2 679 559, 4 251 281) 3 708 724 (3 046 005, 4 670 016) 1.6E-3
carnosine 23 811 (15 639, 77 524) 34 287 (14 160, 119 781) 64 617 (29 846, 195 284) 6.5E-3
aminoadipate 139 402 (119 264, 184 086) 167 760 (130 029, 210 530) 186 821 (144 705, 242 940) 3.3E-3
16:1 carnitine 68 049 (46 259, 99 787) 65 354 (35 653, 77 665) 49 527 (39 008, 71 026) 2.1E-2
14:0 carnitine 9 893 (6 819, 17 108) 8 969 (5 659, 12 834) 7 848 (5 373, 10 960) 3.1E-2
p-creatine 42 102 (30 390, 51 406) 46 713 (36 982, 55 510) 50 600 (37 472, 70 045) 1.8E-2
  1. Values are median peak area for the metabolites (quartile 1, quartile 3)
  2. *P-value significant at the Bonferroni adjusted level of 3.0 × 10−4