Table 6 Cross sectional analysis of total cholesterol tertiles and select metabolites

tryptophan

440 068 (345 130, 586637)

323192 (257580, 429806)

274624 (223120, 324798)

1.7E-9*

18:2 carnitine

60 494 (38 250, 107 981)

49 737 (27 163, 73 344)

32 084 (19 167, 53 863)

9.0E-7*

18:1 carnitine

88 418 (58 090, 144 102)

69 442 (40 568, 103 682)

47 134 (33 127, 74 763)

6.0E-7*

18:0 carnitine

12 789 (10 118, 18 240)

10 879 (7 872, 14 622)

8 466 (6 103, 12 433)

7.7E-5*

arginine

175 576 (136 362, 259 524)

187 566 (132 389, 324 585)

321 420 (216 851, 491 848)

9.6E-6*

10:0 carnitine

52 498 (28 731, 92 694)

40 556 (26 190, 67 085)

34 244 (20 094, 52 420)

7.0E-3

glycocholate

193 580 (60 425, 672 001)

105 938 (61 765, 208 013)

76 985 (42 135, 222 324)

5.6E-3

taurocholate

128 124 (30 180, 379 765)

91 894 (35 067, 188 948)

47 535 (24 706, 128 025)

1.9E-2

GMP

640 409 (341 616, 884 723)

544 860 (409 493, 969 998)

831 864 (565 936, 1 246 583)

8.9E-3

AMP

2 898 935 (2 275 762, 3 795 325)

3 153 490 (2 679 559, 4 251 281)

3 708 724 (3 046 005, 4 670 016)

1.6E-3

carnosine

23 811 (15 639, 77 524)

34 287 (14 160, 119 781)

64 617 (29 846, 195 284)

6.5E-3

aminoadipate

139 402 (119 264, 184 086)

167 760 (130 029, 210 530)

186 821 (144 705, 242 940)

3.3E-3

16:1 carnitine

68 049 (46 259, 99 787)

65 354 (35 653, 77 665)

49 527 (39 008, 71 026)

2.1E-2

14:0 carnitine

9 893 (6 819, 17 108)

8 969 (5 659, 12 834)

7 848 (5 373, 10 960)

3.1E-2

p-creatine

42 102 (30 390, 51 406)

46 713 (36 982, 55 510)

50 600 (37 472, 70 045)

1.8E-2