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Table 7 Cross sectional analysis of systolic blood pressure tertiles and select metabolites

From: Cross-sectional examination of metabolites and metabolic phenotypes in uremia

 

1

2

3

P

14:0 carnitine

10 549 (7 384, 17 510)

7 855 (6 040, 11 626)

6 824 (4 844, 9 486)

9.0E-6*

tryptophan

433 424 (297 696, 573 865)

366 630 (261 744, 444 478)

285 101 (229 380, 350 075)

1.2E-6*

18:1 carnitine

86 406 (56 919, 127 989)

70 273 (47 764, 105 108)

52 275 (32 871, 76 097)

8.7E-6*

18:2 carnitine

55 715 (35 972, 84 528)

44 392 (31 334, 69 607)

30 733 (21 812, 54 084)

5.5E-5*

3:0 carnitine

770 205 (556 166, 976 463)

604 794 (378 770, 724 282)

549 619 (381 463, 708 095)

5.4E-5*

deoxyadenosine

882 (605, 1 330)

831 (455, 1 011)

571 (441, 787)

7.5E-5*

16:1 carnitine

70 042 (50 052, 97 483)

53 904 (39 997, 77 945)

47 577 (36 257, 68 016)

4.2E-4

18:0 carnitine

12 434 (8 777, 17 403)

10 456 (7 790, 15 356)

8 806 (6 509, 12 276)

4.2E-4

carnitine

4 940 542 (4 375 772, 5 974 275)

4 311 636 (3 616 956, 4 936 736)

4 279 513 (3 743 960, 4 756 471)

2.1E-5*

12:0 carnitine

39 844 (22 621, 61 584)

33 433 (22 258, 39 850)

27 094 (17 488, 43 033)

8.5E-3

kynurenic acid

63 185 (35 805, 129 532)

86 131 (60 982, 133 796)

116 334 (67 598, 169 586)

9.4E-4

tyrosine

255 780 (216 337, 319 582)

231 195 (200 964, 273 325)

223 332 (177 881, 270 817)

8.4E-3

ADMA

309 751 (281 198, 370 574)

290 947 (261 258, 344 552)

284 594 (248 154, 328 619)

1.1E-2

taurocholate

103 888 (39 457, 284 746)

65 463 (26 657, 196 110)

59 392 (25 323, 157 090)

1.8E-2

cytidine

60 033 (36 540, 80 779)

51 105 (32 838, 73 636)

44 821 (26 784, 61 200)

2.1E-2

  1. Values are median peak area for the metabolites (quartile 1, quartile 3)
  2. *P-value significant at the Bonferroni adjusted level of 3.0 × 10−4