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Table 2 Creatinine adjusted and unadjusted median urinary concentrations of heavy metals and glyphosate (minimum and maximum values are given in the parenthesis)

From: Simultaneous exposure to multiple heavy metals and glyphosate may contribute to Sri Lankan agricultural nephropathy

Element (Reference range μg/L a)

Creatinine unadjusted (μg/L)

Creatinine adjusted (μg/g creatinine)

SAN patients (group 1)

Controls Endemic (group 2)

Controls non-endemic (group 3)

SAN patients (group 1)

Controls Endemic (group 2)

Controls non-endemic (group 3)

Al (0-20)

8.8 (4.6-32.2)

14.7 (3.6-32.4)

6.8 (3.8-28.4)

19.8 (7.5-89.4)

9.3 (2.6-16.3)

5.3 (2.8-28.7)

Sb (0-1)

3.6 (3.5-3.9)

4.9 (4.4-11)

2.2 (1.6-2.9)

8.2 (3.5-10.3)

3.2 (1.6-12.1)

1.7 (1.3-2.6)

As (0-35)

37.5 (11.1-130.3)

102.0 (14.9-187.8)

29.2 (15.2-40.2)

89.3 (21.6-136.6)

56.2 (17.6-160.5)

21. (11.4-40.2)

Ba (NA)

4.4 (2.9-10.9)

16.5 (7.2-177.9)

33.9 (1.9-7.8)

9.5 (4.5-14.4)

13.7 (5.2-66.4)

2.7 (1.4-7.9)

Cd (0-1.3)

2.5 (2.2-3.1)

4.6 (4.1-6.9)

1.9 (1.1-2.2)

5.5 (2.2-8.6)

3.0 (1.7-8.1)

1.3 (1.0-2.0)

Cr (NA)

22.5 (17.1-52.7)

42.9 (15-77.3)

18.1 (11.5-35.6)

50.3 (17.3-146.4)

27.1 (10.8-52.0)

13.7 (9.3-36.0)

Co (0-1.9)

2.5 (1.6-3.5)

4.7 (2.4-5.9)

1.6 (0.9-2.9)

5.9 (1.6-9.2)

3.3 (1.5-7.8)

1.5 (0.7-2.1)

Cu (15-60)

20.7 (9.6-104.5)

35.9 (11.2-56.1)

13.8 (8.5-39.7)

46.0 (9.7-160.8)

19.6 (4.6-61.6)

10.9 (5.5-29.8)

Fe (100-300)

117.2 (28.4-636.3)

622.2 (248.5-1767)

135.1 (69.6-287.5)

250.5 (55.7-1767.5)

513.8 (171.4-965.8)

106.6 (49.1-290.4)

Pb (0-4)

11.8 (11.5-14.2)

20.0 (18.4-24.5)

9.0 (7.8-9.9)

26.5 (11.6-39.4)

12.9 (7.2-23.3)

6.9 (5.7-9.6)

Mn (0.1-0.9)

2.2 (1.5-6.6)

5.9 (3.5-115.1)

1.6 (1.3-4.2)

4.9 (1.6-18.3)

4.2 (2.2-42.9)

1.3 (0.8-4.2)

Mo (6-190)

47.8 (25-213)

98.8 (38-211.8)

50.1 (20.7-187.6)

108.6 (25.3-591.7)

80.9 (14.2-176.8)

33.9 (16.7-189.5)

Ni (0-6)

5.6 (1.7-24.1)

10.1 (2.6-25.2)

4.7 (1.3-11.5)

12.8 (1.7-66.9)

7.2 (1.9-18.6)

3.4 (1.0-11.6)

Se (0-50)

13.1 (9.7-33.1)

22.8 (10.7-52.4)

11.3 (6.6-27.5)

26.6 (16.9-88.9)

18.5 (4.9-34.1)

8.7 (4.5-24.6)

Sr (NA)

102.3 (26.2-368.2)

471.6 (147.7-940.1)

82.9 (26.2-187.2)

191.2 (51.4-1022.8)

304.1 (106.3-514.4)

63.7 (16.6-189.1)

Sn (NA)

30.0(29.6-39.2)

37.0 (36.4-39.4)

47.7 (38.7-57.4)

68.7 (30.4-95.6)

24.6 (13.2-63.2)

35.7 (27.5-51.3)

Ti (0-2)

122.9 (69.9-807.4)

300.0 (38.3-803.1)

124.5 (60.2-604.1)

251.1 (119.8-2242.8)

291.1 (14.3-553.9)

91.9 (38.1-231.3)

V (0-1)

20.0 (13.4-59.3)

44.9 (18.5-188.7)

18.1 (14.2-24.5)

44.4 (13.5-164.7)

31.6 (13.3-70.4)

13.07 (10.8-20.0)

Zn (300-600)

194.7 (139.2-430.1)

344.6 (32.5-756.6)

203.0 (145.6-277.6)

403.9 (203.8-1194.7)

326.7 (192.2-435.6)

144.0 (94.5-280.4)

Glyphosate (NA)

56.8 (28.2- >80)

73.5 (40.2- > 80)

3.3 (1.2-5.5)

127.6 (61.0-195.1)

82.6 (17.1-195.1)

2.4 (0.8-4.4)

  1. aReference range for creatinine unadjusted urinary excretion (μg/L) given by Mayo clinic Rochester, Minnesota [18], USA. NA-reference range not available