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Table 3 Adjusted and unadjusted associations between interdialytic weight gain and outcomes of interest

From: A retrospective, longitudinal study estimating the association between interdialytic weight gain and cardiovascular events and death in hemodialysis patients

  Relative IDWG Absolute IDWG
Outcomes Unadjusted HR (95 % CI) Adjustedd HR (95 % CI) Unadjusted HR (95 % CI) Adjustedd HR (95 % CI) Adjustedd + postdialysis weight HR (95 % CI)
>3.5 % (vs ref ≤ 3.5 %) >3.5 % (vs ref ≤ 3.5 %) >3 kg (vs ref ≤ 3 kg) >3 kg (vs ref ≤ 3 kg) >3 kg (vs ref ≤ 3 kg)
MI 1.14 (1.05–1.24) 1.18 (1.08–1.28) 0.94 (0.86–1.03) 1.02 (0.93–1.12) 1.07 (0.97–1.18)
HF 1.19 (1.14–1.24) 1.20 (1.15–1.26) 1.08 (1.03–1.13) 1.14 (1.09–1.20) 1.20 (1.14–1.26)
MACEa 1.19 (1.12–1.27) 1.21 (1.14–1.29) 0.98 (0.92–1.05) 1.04 (0.97–1.12) 1.11 (1.03–1.19)
MACE+b 1.18 (1.14–1.23) 1.22 (1.17–1.26) 1.05 (1.01–1.10) 1.14 (1.09–1.19) 1.19 (1.14–1.25)
CV mortalityc 1.23 (1.14–1.34) 1.23 (1.13–1.34) 1.00 (0.91–1.09) 1.04 (0.94–1.15) 1.12 (1.02–1.24)
All-cause mortality 1.22 (1.16–1.29) 1.26 (1.20–1.33) 0.97 (0.92–1.03) 1.07 (1.00–1.13) 1.17 (1.10–1.24)
  1. Abbreviations: CI confidence interval, CV cardiovascular, MI myocardial infarction, HF heart failure/volume overload, HR hazard ratio, IDWG interdialytic weight gain, MACE major adverse cardiovascular event, ref reference
  2. aDefined as nonfatal myocardial infarction, nonfatal ischemic stroke, or CV death
  3. bDefined as events comprising MACE as well as arrhythmia, nonfatal hemorrhagic stroke, or hospitalization for heart failure
  4. cDefined as death attributed to MI, atherosclerotic heart disease, cardiac arrhythmia, congestive HF, cardiomyopathy, cardiac arrest, valvular heart disease, pulmonary edema, or cerebrovascular accident including intracranial hemorrhage or ischemic brain damage/anoxic encephalopathy
  5. dHRs were adjusted for age, race, sex, etiology of end-stage renal disease, prior renal transplant, access type, and baseline diabetes, uncontrolled hypertension, HF, MI, atrial fibrillation, and ischemic/hemorrhagic stroke or transient ischemic attack