Fig. 3

Patient dispositiona. aCONSORT 2010 flow diagram was provided as Additional file 1. * The number of the patients who were excluded during the Run-in period (n = 279) was calculated by adding the number of the patients who dropped out during the Run-in period (n = 278) and the patient who was excluded before the initiation of the study treatment (n = 1). ** Ten patients whose SCr values measured less than three points after Week 4 of the Treatment period were excluded from 112 patients randomized. As a results, 102 patients (32 patients in the 120 μg group, 36 patients in the 240 μg group and 34 patients in the placebo group) were included in the full analysis set (FAS). *** If there were multiple reasons for discontinuation, the main reason was used for calculation