Fig. 1

Overlap in main molecular - histopathological - clinical phenotypes in kidney allografts: The molecular phenotype in renal allografts presents as changes in groups / sets of genes/transcripts which are strongly correlated with each other. Few “top” genes can be selected to represent specific biological processes like T cell infiltration and activation. These molecular phenotypes correlate with related histological lesions and other serological parameters, e.g., microcirculation inflammation and DSA with increased expression of endothelial and NK cell genes in antibody-mediated rejection. Of note is that to some extent the different molecular phenotypes overlap between diagnostic entities and thus cannot be considered absolutely specific, i.e., similar to non-specific histological lesions