Table 3 Relationship between independent variables and appropriateness of dose adjustment of prescription entries in Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia, August 2013

Drugs prescribed

Cimetidine

15

3

0.00

0.060 (0.013, 0.280)

0.013 (0.001, 0.15)^a

Spironolactone

2

14

0.24

2.100 (0.369, 11.96)

4.639 (0.353, 60.919)

Vancomycin

10

4

0.013

0.120 (0.027, 0.525)

0.045 (0.004, 0.525)^a

Ceftazidime

7

4

0.04

0.171 (0.037, 0.792)

0.067 (0.005, 0.894)^a

Digoxin

7

1

0.008

0.043 (0 .004, 0.421)

0.009 (0.000, 0.297)^a

Enalapril

6

0

0.998

0.000 (0.000, −)

0.000 (0.000, −)

Allopurinol

0

5

0.999

4.846 (0 .000, −)

1.365 (0.000, −)

Ciprofloxacin

3

1

0.055

0.100 (0.009, 1.147)

0.017 (0.000, 1.091)

Fluconazole

1

3

0.969

0.90(0 .078, 10.327)

1.071 (0.033, 34.663)

Cotrimoxazole

0

3

0.99

4.846 (0.000,-)

4.686 (0.000, −)

Other

6

20

-

1

1

Stage 3

51

32

0.016

0.157 (0.031, 0.786)

64.159 (0.159, 2.59)

Stage 4

4

18

0.174

1.125 (0.170 7.452)

587.70 (4.040, 8.549)^a

Stage 5

2

8

0.012

1

1

SCr (mean)

1.83

2.83

0.02

1.820 (1.232, 2.690)

129.95 (6.431, 2.626)^a

BUN (mean)

85.2

100.4

0.027

1.004 (0.998, 1.010)

0.976 (0.956, 0.997)^a

Renal

10

18

0.684

2.115 (0.877, 5.10)

0.612 (0.057, 6.534)

Non renal

47

40

-

1

1

Yes

50

53

0.098

1.484 (0.442, 4.98)

11.77 (0.635, 218.265)

No

7

5

-

1

1