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Table 3 Relationship between independent variables and appropriateness of dose adjustment of prescription entries in Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia, August 2013

From: Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia

Variables Appropriately adjusted P-value OR (95 %) CI
  Yes No   COR AOR
Drugs prescribed      
Cimetidine 15 3 0.00 0.060 (0.013, 0.280) 0.013 (0.001, 0.15)a
Spironolactone 2 14 0.24 2.100 (0.369, 11.96) 4.639 (0.353, 60.919)
Vancomycin 10 4 0.013 0.120 (0.027, 0.525) 0.045 (0.004, 0.525)a
Ceftazidime 7 4 0.04 0.171 (0.037, 0.792) 0.067 (0.005, 0.894)a
Digoxin 7 1 0.008 0.043 (0 .004, 0.421) 0.009 (0.000, 0.297)a
Enalapril 6 0 0.998 0.000 (0.000, −) 0.000 (0.000, −)
Allopurinol 0 5 0.999 4.846 (0 .000, −) 1.365 (0.000, −)
Ciprofloxacin 3 1 0.055 0.100 (0.009, 1.147) 0.017 (0.000, 1.091)
Fluconazole 1 3 0.969 0.90(0 .078, 10.327) 1.071 (0.033, 34.663)
Cotrimoxazole 0 3 0.99 4.846 (0.000,-) 4.686 (0.000, −)
Other 6 20 - 1 1
Stage
Stage 3 51 32 0.016 0.157 (0.031, 0.786) 64.159 (0.159, 2.59)
Stage 4 4 18 0.174 1.125 (0.170 7.452) 587.70 (4.040, 8.549)a
Stage 5 2 8 0.012 1 1
SCr (mean) 1.83 2.83 0.02 1.820 (1.232, 2.690) 129.95 (6.431, 2.626)a
BUN (mean) 85.2 100.4 0.027 1.004 (0.998, 1.010) 0.976 (0.956, 0.997)a
Reason of admission
Renal 10 18 0.684 2.115 (0.877, 5.10) 0.612 (0.057, 6.534)
Non renal 47 40 - 1 1
Comorbidity
Yes 50 53 0.098 1.484 (0.442, 4.98) 11.77 (0.635, 218.265)
No 7 5 - 1 1
  1. aStatistically significant, COD crude odds ratio; AOR adjusted odds ratio