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Table 5 Validation group: Correlations, bias, precision and accuracy of the different GFR prediction methods and measured 24hU-CrCl

From: Quantification of excretory renal function and urinary protein excretion by determination of body cell mass using bioimpedance analysis

   Correlation coefficient R SEE† BIAS Median difference† ABSOLUTE BIAS† PRECISION IQR (P25, P75) of differences† ACCURACY
P15 (%) P30 (%)
All subjects (N = 31) mCrCl 0.972*** 8.8 0 4.4 7.9 (-4.3, 3.6) 27 (87)a 30 (97)bcd
4vMDRD 0.935*** 11.4 −8.3 8.9 13.7 (-18.8, -5.2) 8 (26) 25 (81)
CKD-EPI 0.932*** 13.0 −7.0 7.2 12.1 (-15.7, -3.6) 9 (29) 26 (84)
CG-CrCl 0.920*** 14.2 −4.4 7.1 9.0 (-8.7, 0.4) 17 (55) 28 (90)
Male (N = 15) mCrCl 0.958*** 11.3 0.8 7.3 15.5 (-11.5, 4.0) 13 (87) 15 (100)
4vMDRD 0.961*** 9.0 −17.0 17.0 21.9 (-28.7, -6.8) 3 (20) 12 (80)
CKD-EPI 0.967*** 9.2 −8.4 8.4 17.1 (- 23.3, -6.2) 4 (27) 14 (93)
CG-CrCl 0.965*** 9.6 −8.8 8.8 11.2 (-15.5, -4.3) 8 (53) 14 (93)
Female (N = 16) mCrCl 0.967*** 5.9 −0.6 4.2 7.3 (-4.2, 3.1) 15 (94) 15 (94)
4vMDRD 0.915*** 10.8 −5.9 7.4 6.3 (-10.2, -3.9) 5 (31) 11 (69)
CKD-EPI 0.916*** 12.4 −4.8 5.9 6.7 (-8.7, -1.9) 5 (31) 11 (69)
CG-CrCl 0.893*** 14.4 −1.1 4.0 7.6 (-5.6, 1.9) 8 (50) 13 (81)
CrCl > 60 (N = 11) mCrCl 0.677* 10.3 0.7 11 17.8 (-11.5, 6.3) 10 (91) 11 (100)
4vMDRD 0.214º 15.5 −22.0 24.4 22.1 (-34.5, -12.4) 2 (18) 8 (73)
CKD-EPI 0.153º 16.8 −18.4 19.0 23.6 (-25.5, -1.9) 4 (36) 10 (91)
CG-CrCl 0.247º 20.3 −8.1 9.4 13.0 (-17.8, -4.8) 4 (36) 10 (91)
CrCl 30 to 60 (N = 11) mCrCl 0.756** 7.0 −3.8 5.9 7.8 (-5.2, 2.7) 10 (91) 11 (100)
4vMDRD 0.744** 4.7 −8.0 8.0 5.4 (-10.8, -5.4) 4 (36) 9 (82)
CKD-EPI 0.731* 5.0 −7.0 7.0 5.1 (-10.8, -5.7) 3 (27) 9 (82)
CG-CrCl 0.695* 7.1 −3.3 5.1 6.8 (-7.5, -0.6) 6 (55) 11 (100)
CrCl < 30 (N = 9) mCrCl 0.767** 3.9 1.4 1.5 2.3 (-0.2, 2.1) 8 (89) 8 (89)
4vMDRD 0.672* 2.8 −6.2 6.2 3.0 (-7.2, -4.2) 2 (22) 7 (78)
CKD-EPI 0.593º 3.4 −6.4 6.4 4.0 (-8.2, -4.2) 2 (22) 7 (78)
CG-CrCl 0.300º 7.4 −0.6 4.2 6.0 (-4.2, 1.9) 4 (44) 7 (78)
BMI > 30 (N = 8) mCrCl 0.989*** 6.8 0.1 2.7 7.3 (-5.9, 1.4) 7 (88) 8 (100)
4vMDRD 0.876** 21.2 −10.3 16.3 19.7 (-25.5, -5.9) 0 3 (38)
CKD-EPI 0.861** 24.6 −8.8 14.1 16.2 (-22.0, -5.9) 0 6 (75)
CG-CrCl 0.874** 25.5 −6.1 7.1 9.5 (-7.7, 1.8) 4 (93) 7 (88)
BMI > 25 bis 29.9 (N = 16) mCrCl 0.956*** 10.8 −0.4 4.3 8.1 (-4.3, 3.8) 14 (88) 15 (94)
4vMDRD 0.963*** 7.7 −6.8 6.8 10.3 (-14.2, -3.9) 7 (44) 13 (81)
CKD-EPI 0.972*** 7.5 −6.7 6.7 9.0 (-12.0, -3.0) 5 (31) 13 (81)
CG-CrCl 0.963*** 8.0 −3.1 7.8 10.7 (-10.0, 0.7) 9 (56) 14 (88)
BMI < 24.9 (N = 7) mCrCl 0.984*** 6.5 0.8 5.9 (-11, 0.8)†† 7 (100) 7 (100)
4vMDRD 0.983*** 5.6 −11.0 11.0 (-33.0, -5.3)†† 1 (14) 6 (86)
CKD-EPI 0.971*** 8.7 −6.0 6.0 (-26.0, -0.8)†† 3 (43) 7 (100)
CG-CrCl 0.950*** 10.7 −4.2 4.2 (-32.7, 1.8)†† 4 (57) 7 (100)
  1. ***p < 0.001; **p < 0.01; *p < 0.05; ºnon significant
  2. †displayed in mL/min/1.73 m2; ††(Minimum, Maximum)
  3. ap < 0.005 vs the three other methods; bp = 0.07 vs 4vMDRD; cp = 0.21 vs CKD-EPI;dp = 0.50 vs CG
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