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Table 1 Baseline data of the patient on admission in November 2007

From: A case of severe osteomalacia caused by Tubulointerstitial nephritis with Fanconi syndrome in asymptomotic primary biliary cirrhosis

Peripheral blood

Urinalysis

 white blood cell count 6800/μl

pH 6.0

 hemoglobin 13.5 g/dl

protein (3+)

 platelet 20.1 × 104/μl

urine sugar (4+)

Biochemistry

 total protein 8.7 g/dl,

bone specific alkaline phosphatase 67.5 IU/l

 albumin 4.6 g/dl

γ-glutamyl transpeptidase 18 IU/l

 total bilirubin 0.7 mg/dl

1,25-dihydroxyvitamine D 11.0 pg/dl

 blood urea nitrogen 19.4 mg/dl

intact parathyroid hormone 46 pg/ml

 creatinine 1.4 mg/dl

parathyroid hormone-related protein <1.1 pg/ml

 uric acid 1.5 mg/dl

calcitonin 24 pg/ml

 sodium 137.8 mEq/l

osteocalcin 7.6 ng/ml

 potassium 2.8 mEq/l

fibroblast growth factor-23 22.1 pg/ml

 chloride 108 mEq/l

IgG 1228 mg/dl

 calcium 9.5 mg/dl

IgA 201 mg/dl

 phosphorus 2.3 mg/dl

IgM 1084 mg/dl

 fasting plasma glucose 98 mg/dl

anti-nuclear antibody 1:1280

 hemoglobin A1c 4.8 %

anti-SS-A/Ro antibody (−)

 total cholesterol 249 mg/dl

anti-SS-B/La antibody (−)

 c-reactive protein 0.17 mg/dl

anti-double stranded DNA antibody 3 IU/ml

 lactate dehydrogenase 191 IU/l

Shirmer test (−)

 aspartate aminotransferase 23 IU/l

serum M protein(−)

 alanine aminotransferase 24 IU/l

urine Bence Jones Protein (−)

 alkaline phosphatase 663 IU/l

anti-mitochondrial M2 antibody 10.0 index

Arterial blood gas analysis (Room Air)

24-h urine analysis

 pH 7.306

Tmp/GFR 0.91

 pO2 89.0 torr

%TRP 37.9 %

 pCO2 35.9 torr

FEUA 43.9 %

 HCO3− 17.4 mmol/l

glucose 12.83 g

bicarbonate loading test

generalized aminoaciduria(+)

 FEHCO3− 13.25 %

protein 2.464 g

 U-Bpco2 50.1 mmHg

FEca 11.878 %,

 

CrCl 45.76 ml/min/1.73 m2