Genetic predisposition to acute kidney injury – a systematic review

BMC Nephrology

Table 2 Characteristics of articles

Characteristic	N	References
Clinical setting
Post cardiac surgery	12	[24, 25, 36–39, 42–44, 46–48]
ICU treatment	6	[26, 33, 34, 40, 41, 49]
Hospitalization with kidney injury	5	[22, 28–31]
Dialysis	1	[27]
Other	4	[32, 35, 45, 50]
Study design
Prospective cohort	23	[22, 24–30, 32, 33, 36–40, 42–44, 46–50]
Prospective case–control	4	[31, 35, 41, 45]
Retrospective case-cohort	1	[34]
Center of data acquisition
Single	14	[25, 26, 33, 36, 37, 40, 41, 43–48, 50]
Multi	12	[22, 27–32, 34, 35, 39, 42, 49]
Not applicable	2	[24, 38]
Definition of AKI
RIFLE	8	[33, 36–40, 42, 46]
AKIN	7	[22, 30–32, 34, 41, 49]
Renal-SOFA	1	[26]
Administration of RRT	2	[44, 47]
Creatinine level	4	[28, 29, 35, 45]
Not applicable	6	[24, 25, 27, 43, 48, 50]
Studied polymorphisms
1 polymorphism	11	[24, 29, 30, 33, 37, 39, 43, 46–49]
1 gene, several polymorphisms	4	[22, 26, 31, 32]
Several genes	12	[25, 27, 28, 35, 36, 38, 40–42, 44, 45, 50]
GWAS	1	[34]
Ethnicity
Caucasian	9	[31, 33–36, 40, 46–48]
Mixed	10	[22, 24, 25, 27–30, 32, 49, 50]
Not applicable	9	[26, 37–39, 41–45]
Main outcome
AKI	26	[22, 25–34, 36–50]
Other	2	[24, 35]

Abbreviations: AKI Acute Kidney Injury, AKIN Acute Kidney Injury Network -classification, GWAS Genome-Wide Association Study, ICU Intensive Care Unit, RIFLE Risk Injury Failure Loss of function End stage -classification, RRT renal replacement therapy, SOFA, Sequential Organ Failure Assessment score

ISSN: 1471-2369