Table 2 Clinical Characteristics of Patients in the Global aHUS Registry
From: The global aHUS registry: methodology and initial patient characteristics
Characteristic | Pediatric patients (n = 201)a | Adult patients (n = 315)a | Total (N = 516)a |
|---|---|---|---|
Age at initial symptoms, years | |||
n | 198 | 310 | 508 |
Mean (SD) | 4.1 (3.9) | 33.6 (18.3) | 22.1 (20.4) |
Median (range) | 2.9 (0.0–16.3) | 31.1 (0.1–81.8) | 19.2 (0.0–81.8) |
Age categories, n (%) | |||
<2 | 87 (43.9) | 12 (3.9) | 99 (19.5) |
2 to <5 | 40 (20.2) | 9 (2.9) | 49 (9.6) |
5 to <12 | 60 (30.3) | 14 (4.5) | 74 (14.6) |
12 to <18 | 11 (5.6) | 11 (3.5) | 22 (4.3) |
18 to <30 | — | 95 (30.6) | 95 (18.7) |
30 to <40 | — | 71 (22.9) | 71 (14.0) |
40 to <50 | — | 34 (11.0) | 34 (6.7) |
≥50 | — | 64 (20.6) | 64 (12.6) |
Age at diagnosis, years | |||
n | 201 | 313 | 514 |
Mean (SD) | 4.3 (4.0) | 34.5 (17.9) | 22.7 (20.5) |
Median (range) | 3.1 (0.0–16.3) | 31.5 (0.1–81.8) | 19.7 (0.0–81.8) |
Age categories, n (%) | |||
<2 | 86 (42.8) | 10 (3.2) | 96 (18.7) |
2 to <5 | 39 (19.4) | 6 (1.9) | 45 (8.8) |
5 to <12 | 63 (31.3) | 11 (3.5) | 74 (14.4) |
12 to <18 | 13 (6.5) | 14 (4.5) | 27 (5.3) |
18 to <30 | — | 98 (31.3) | 98 (19.1) |
30 to <40 | — | 71 (22.7) | 71 (13.8) |
40 to <50 | — | 35 (11.2) | 35 (6.8) |
≥50 | — | 68 (21.7) | 68 (13.2) |
Disease duration from diagnosis to enrollment, years | |||
n | 201 | 313 | 514 |
Mean (SD) | 4.0 (4.1) | 5.2 (7.8) | 4.7 (6.6) |
Median (range) | 2.4 (0.0–17.1) | 1.6 (0.0–50.6) | 1.9 (0.0–50.6) |
Family history of aHUS, n (%) | 41 (20.4) | 58 (18.4) | 99 (19.2) |
History of PE/PI, n (%) | 107 (53.2) | 204 (64.8) | 311 (60.3) |
History of dialysis, n (%) | 107 (53.2) | 200 (63.5) | 307 (59.5) |
History of kidney transplantation, n (%) | 25 (12.4) | 76 (24.1) | 101 (19.6) |
History of eculizumab use prior to enrollment, n (%) | 106 (52.7) | 168 (53.3) | 274 (53.1) |