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Table 1 Patient characteristics for the cross-sectional analysis (n = 199). Values shown as mean ± SD or median (interquartile range) and p values obtained from comparison between the 3 mGFR groups, calculated from a one-way ANOVA or χ2 test

From: The Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation does not improve the underestimation of Glomerular Filtration Rate (GFR) in people with diabetes and preserved renal function

Parameter

All (n=199)

mGFR <60 (n=60)

mGFR 60-90 (n=63)

mGFR >90 (n=76)

p value

Age (Yr)

62.8 ± 12.7

70.9 ± 10.8

65.4 ± 9.2

54.3 ± 11.3

<0.001

Gender (% males)

67

65

65

70

0.79

Type diabetes (% T1/T2)

25/75

15/85

21/79

37/63

0.009

Duration of diabetes (Years)

18.0 ± 11.4

20.9 ± 12.0

19.1 ± 12.7

14.8 ± 8.9

0.007

Height (cm)

168.6 ± 9.3

167.5 ± 9.2

167.5 ± 9.6

170.5 ± 8.9

0.12

Weight (kg)

88.8 ± 21.1

85.8 ± 19.6

89.3 ± 24.5

90.7 ± 19.3

0.41

BMI (kg/m2)

31.1 ± 7.0

30.2 ± 6.0

31.8 ± 8.5

31.1 ± 6.1

0.46

mGFR (ml/min/1.73m2)

80.0 ± 30.9

44.2 ± 10.8

75.5 ± 9.8

111.8 ± 17.0

<0.001

MDRD (ml/min/1.73m2)

78.4 ± 28.2

48.2 ± 13.3

79.5 ± 17.5

100.8 ± 22.5

<0.001

CKD-EPI (ml/min/1.73m2)

78.4 ± 24.9

49.5 ± 14.2

80.7 ± 15.2

99.4 ± 13.1

<0.001

AER (μg/min)

10.4 (4.3, 26.3)

20.7 (7.6, 71.3)

5.8 (3.5, 19.1)

8.6 (4.3, 20.7)

0.47

AER (% normo/micro/macro)

69.2/24.7/6.1

54.2/32.2/13.6

69.8/23.8/6.4

80.3/19.7/0

0.004

HbA1C (%)

7.60 ± 1.1

7.35 ± 1.0

7.42 ± 0.085

7.94 ± 1.3

0.002

HbA1C (mmol/mole)

60

57

58

63

0.002

Systolic blood pressure (mmHg)

131.9 ± 14.6

135.2 ± 17.4

132.7 ± 15.2

128.7 ± 10.8

0.03

Diastolic blood pressure (mmHg)

71.4 ± 10.1

67.9 ± 9.6

72.2 ± 10.9

73.5 ± 9.2

0.005

Any blood pressure therapy (%)

81

88

82

76

0.21

ACE inhibitor therapy (%)

47

52

42

46

0.65

Lipid lowering therapy (%)

83

88

89

76

0.08

Fenofibrate therapy (%)

8

11

8

5

0.55

Retinopathy ()

53

61

51

48

0.34

IHD (%)

31

39

38

19

0.02

CVD (%)

5

5

7

3

0.56

PVD (%)

13

25

12

4

0.002

History of macrovascular disease (%)

40

49

48

23

0.002

  1. BMI Body Mass Index, mGFR measured Glomerular Filtration Rate, MDRD Modification of Diet in Renal Disease, CKD-EPI Chronic Kidney Disease-Epidemiology Collaboration, AER Albumin Excretion Rate, Normo Normoalbuminuria, Micro Microalbuminuria, Macro Macroalbuminuria, HbA1c Glycated Haemoglobin, ACE Angiotensin Converting Enzyme, IHD Ischaemic Heart Disease, CVD Cerebrovascular Disease, PVD Peripheral Vascular Disease