Hazard ratio (95 % CI) |
---|
Variables | Unadjusted for GFR | Adjusted for mGFR | Adjusted for eGFRcr | Adjusted for eGFRcys |
Not frail (reference) | 1.00 | – | – | – |
Intermediate frail | 1.47 (1.14–1.90) | 1.43 (1.11–1.83) | 1.45 (1.13–1.87) | 1.42 (1.10–1.83) |
Frail | 1.71 (1.26–2.30) | 1.48 (1.08–2.00) | 1.57 (1.15–2.10) | 1.51 (1.10–2.10) |
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Abbreviations: mGFR measured glomerular filtration rate by Iothalamate, eGFRcr creatinine estimated glomerular filtration rate, eGFRcys by CKD-EPI equation. All models are adjusted for urine protein, sex, age, race, BMI; body mass index and albumin quartiles and group randomization by diet and blood pressure assignment. All GFR measures are per 10 ml/min/1.73 m2