Gastrointestinal symptoms, inflammation and hypoalbuminemia in chronic kidney disease patients: a cross-sectional study

Table 5 How serum albumin levels vary by eGFR (pathway ⑤)

	Outcomes
	Absolute change in serum albumin, g/dL (95 % CI)
Predictor eGFR (ml/min/1.73 m²)	Unadjusted	Adjusted for GI symptom score	Adjusted for CRP	Adjusted for 24-hr albuminuria	Multivariable adjusted^a	Fully adjusted^b
≥60(n = 370)	reference	reference	reference	reference	reference	reference
45–60 (n = 1166)	−0.06 (−0.11 ~ −0.003) p = 0.04	−0.06 (−0.11 ~ −0.003) p = 0.04	−0.05 (−0.10 ~ 0.002) p = 0.06	−0.03 (−0.08 ~ 0.02) p = 0.2	−0.08 (−0.13 ~ −0.03) p = 0.002	−0.03 (−0.07 ~ 0.02) p = 0.2
30–44 (n = 1375)	−0.16 (−0.22 ~ −0.11) p < 0.001	−0.16 (−0.21 ~ −0.11) p < 0.001	−0.15 (−0.21 ~ −0.10) p < 0.001	−0.09 (−0.14 ~ −0.05) p < 0.001	−0.16 (−0.21 ~ −0.11) p < 0.001	−0.07 (−0.11 ~ −0.02) p = 0.005
<30 (n = 688)	−0.21 (−0.27 ~ −0.15) p < 0.001	−0.20 (−0.26 ~ −0.14) p < 0.001	−0.20 (−0.25 ~ −0.14) p < 0.001	−0.08 (−0.13 ~ −0.03) p = 0.003	−0.19 (−0.24 ~ −0.13) p < 0.001	−0.04 (−0.09 ~ 0.01) p = 0.1

^aAdjusted for age, sex, race/ethnicity, diabetes
^bAdjusted for age, sex, race/ethnicity, diabetes, CRP, GI symptom score, 24-hour albuminuria

ISSN: 1471-2369