Table 1 Clinical summary of renal TMA in HLH
Patient number | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
Age | 63 | 18 | 24 | 18 | 60 |
Gender | Female | Female | Male | Female | Female |
Race | Caucasian | Asian | NA | Asian | Asian |
Etiology of HLH | CMV | Idiopathic | Parvovirus B19 | Idiopathic | Idiopathic |
Renal manifestation | |||||
Proteinuria | Positive | Positive | Positive | Positive | Positive |
24 hr urine | 7.3 g/day | 9.6 g/day | NA | >3.5 g/day | NA |
Urine PCR | NA | NA | 510 mg/g | NA | 906 mg/g |
Microscopic hematuria | Positive | Positive | Negative | Positive | Positive |
Oliguria | Absent | NA | Absent | Absent | Yes |
Dialysis | HD | No | No | No | HD |
Treatment | |||||
Steroids | Yes | Yes | Yes | Yes | Yes |
IVIG | Yes | Yes | Yes | Yes | Yes |
Cytotoxic agents | No | No | No | No | Yes |
Outcome | Dead | Cured | Cured | Cured | Cured |
Reference | Thaunat et al.,[4] | Thaunat et al.,[4] | Ardalan et al.,[13] | Chiang et al.,[18] | Our case |