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Fig. 1 | BMC Nephrology

Fig. 1

From: Membranoproliferative glomerulonephritis recurrence after kidney transplantation: using the new classification

Fig. 1

Histological changes of MPGN in kidney transplant biopsies. Typical light microscopic (LM), electron microscopy (EM) and immunofluorescence (IF) finding in cases previously classified as MPGN. Panel on left demonstrates a case reclassified as ICGN with C3 abnormalities, including (a) the classic MPGN pattern glomerulonephritis on LM (hematoxylin and eosin ×400), (b) large subendothelial electron dense deposits on EM (×1250 K) and granular mesangial and capillary wall staining for both (c) IgG and (d) C3 on IF. The panel on the right shows a case reclassified as a C3 glomerulopathy, with (e) a similar MPGN pattern on light microscopy (hematoxylin and eosin ×400), (f) smaller subendothelial deposits on EM (×7100) and granular mesangial and capillary wall staining for (g) C3, but no significant staining for (h) IgG. EM images stained with lead citrate/ uranyl acetate. Immunofluorescence stains are FITC-conjugated goat anti-human IgG (MP Biomedical) and FITC-conjugated goat anti-human C3 (Kent) all at × 400

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