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Table 4 Effect of study intervention on cognitive testing after 12 months compared to baseline

From: Cognitive changes associated with switching to frequent nocturnal hemodialysis or renal transplantation

Testa

Cognitive Domain

Study Group

Percent Change (12 mon – Baseline)/(Group Baseline Average)b

P-value

Group x Time Interaction

P-value

AVLT_LA_T1

Memory (auditory)

Control

1.8

0.726

 

Nocturnal

13.8

0.307

0.743

Transplant

−1.5

0.965

 

AVLT_LA_T5

Memory (auditory) & Learning

Control

9.5

0.081

 

Nocturnal

14.8

0.048*

0.332

Transplant

20.9

0.003*

 

AVLT Learning Score

Memory (auditory) & Learning

Control

14.9

0.213

 

Nocturnal

9.9

0.681

0.609

Transplant

35.9

0.009*

 

AVLT_LA_IR

Immediate Recall Memory (auditory)

Control

16.2

0.151

 

Nocturnal

3.2

0.864

0.264

Transplant

31.9

0.002*

 

AVLT_LA_DR

Delayed Recall Memory (auditory)

Control

−0.6

0.825

 

Nocturnal

−5.4

0.242

0.021*

Transplant

23.3

0.012*

 

BVMT_T1

Memory (visual-motor)

Control

−10.0

0.191

 

Nocturnal

−11.7

0.203

0.619

Transplant

5.6

0.565

 

BVMT_T3

Memory (visual-motor) & Learning

Control

−4.7

0.341

 

Nocturnal

−9.2

0.221

0.215

Transplant

0.9

0.933

 

BVMT Learning Score

Memory (visual-motor) & Learning

Control

8.8

0.76

 

Nocturnal

−2.3

0.82

0.302

Transplant

−2.2

0.558

 

BVMT_DR

Delayed Recall Memory (visual-motor)

Control

6.1

0.439

 

Nocturnal

−18.5

0.043*

0.164

Transplant

−3.6

0.500

 

Letter Number Sequence

Working Memory

Control

5.2

0.594

 

Nocturnal

−0.9

0.982

0.277

Transplant

10.2

0.082

 

N-Back

Working Memory, Attention (Executive function)

Control

−2.3

0.093

 

Nocturnal

14.0

0.544

0.854

Transplant

18.0

0.995

 

Digit Symbol

Psychomotor processing speed, (Executive Function)

Control

13.4

0.000*

 

Nocturnal

3.7

0.305

0.682

Transplant

12.2

0.054*

 

Chooser (Choice Reaction Time)

Psychomotor processing speed

Control

2.0

0.070

 

Nocturnal

−0.6

0.752

0.591

Transplant

10.1

0.586

 

Buttons (Motor Tracking)

Psychomotor processing speed

Control

−0.0

0.369

 

Nocturnal

−1.2

0.946

0.558

Transplant

−7.4

0.275

 

Trails A

Psychomotor Processing Speed & attention

Control

4.8

0.649

 

Nocturnal

−0.2

0.907

0.660

Transplant

−5.1

0.934

 

Trails B

Executive Function

Control

−4.5

0.867

 

Nocturnal

−20.9

0.187

0.156

Transplant

−3.0

0.311

 

Verbal Fluency (COWAT)

Language & Executive Function

Control

−23.8

0.001*

 

Nocturnal

−14.6

0.080

0.017*

Transplant

3.7

0.929

 
  1. aSee Table 1 for details on cognitive tests. * P<0.05. AVLT_LA_T1, Auditory Verbal Learning Test, word list A, first administration; AVLT_LA_T5, Auditory Verbal Learning Test, word list A, fifth administration; AVLT Learning Score, represents the difference in the maximum number of words recalled on the 4th or 5th administration minus the baseline recall; AVLT_LA_IR, Auditory Verbal Learning Test, word list A, immediate recall; represents immediate recall from word list A after completion of the distractor list of 15 different words; AVLT_LA_DR, Auditory Verbal Learning Test, word list A, delayed recall; represents delayed recall from word list A, 30 min after completion of the distractor list of 15 different words; BVMT_T1, Brief Visuospatial Memory Test, first administration; BVMT_T3, Brief Visuospatial Memory Test, third administration; BVMT Learning Score, measures the mean difference in the maximum and baseline performance on the BVMT at that study visit; BVMT_DR, Brief Visuospatial Memory Test, delayed recall, measures recall of the original figures following a 25-min delay
  2. bPercent change was computed as the difference between the twelve month visit and baseline visit divided by the average baseline score for the intervention group
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BMC Nephrology

ISSN: 1471-2369

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