Table 2 Proteinuria reduction and treatment response in patients with FSGS treated with Acthar gel
From: Acthar gel in the treatment of nephrotic syndrome: a multicenter retrospective case series
Patient | Previous IST/CT | Concurrent medications | Serum albumin | SCr | Proteinuria | Treatment response |
|---|---|---|---|---|---|---|
Pre-Acthar | Pre-Acthar | |||||
Pre-Acthar | Post-Acthar % change (mg/dL) | Post-Acthar % change (mg/d) | ||||
Post-Acthar (g/dL) | ||||||
1 | Prednisone, cyclosporine, cyclophosphamide | ACEI, cyclosporine | 1.7 | 1.7 | 6700 | Partial remission |
2.7 | 1.6 | 3300 | ||||
−5.9 | −50.7 | |||||
2 | Prednisone, cyclosporine, MMF, tacrolimus, rituximab | Tacrolimus, MMF | 3.0 | 0.9 | 5800 | Partial remission |
3.4 | 0.8 | 2016 | ||||
−11.1 | −65.2 | |||||
3 | Prednisone | None | 3.2 | 2.2 | 5000 | Clinical response |
3.8 | 2.2 | 3422 | ||||
0 | −31.6 | |||||
4 | None | ARB | 3.9 | 4.8 | 7900 | Partial remission |
4.0 | 6.7 | 2300 | ||||
39.6 | −70.9 | |||||
5 | None | ARB | 3.2 | 3.2 | 3840 | Early termination |
NA | NA | NA | ||||
NA | NA | |||||
6 | Prednisone, cyclosporine | ARB, ACEI cyclosporine | 2.8 | 3.0 | 7500 | Partial remission |
3.9 | 2.5 | 1768 | ||||
−16.7 | −76.4 | |||||
7 | Prednisone, cyclosporine | ARB, ACEI cyclosporine | 3.1 | 1.1 | 5280 | Clinical response |
3.6 | 1.3 | 3560 | ||||
18.2 | −32.6 | |||||
8 | None | ACEI | NA | 1.2 | 4000 | Partial remission |
NA | 1.1 | 765 | ||||
−8.3 | −80.9 | |||||
9 | Prednisolone, methotrexate | ACEI, prednisolone | 3.1 | 1.6 | 9306 | Partial remission |
3.3 | 2.0 | 2773 | ||||
25.0 | −70.2 | |||||
10 | MMF | ACEI, MMF | NA | 4.4 | 2830 | Clinical response |
4.0 | 5.0 | 1629 | ||||
13.6 | −42.4 | |||||
11 | Prednisone | ARB | 3.5 | 2.4 | 3500 | Partial remission |
3.7 | 3.1 | 750 | ||||
29.2 | −78.6 | |||||
12 | Prednisone | ACEI | 3.8 | 1.5 | 5700 | Early termination (Partial remission) |
4.0 | 1.2 | 1500a | ||||
−20.0 | −73.7 | |||||
13 | Prednisone, cyclosporine | None | 3.2 | 3.1 | 3250 | Clinical response |
3.5 | 4.1 | 2073 | ||||
32.3 | −36.2 | |||||
14 | Prednisone, cyclosporine | ACEI | 3.7 | 2.5 | 2500 | Partial remission |
NA | 3.0 | 1246 | ||||
20.0 | −50.2 | |||||
15 | Prednisone, cyclosporine, MMF | ACEI | 3.6 | 1.4 | 4070 | No response |
3.3 | 1.5 | 3930 | ||||
7.1 | −3.4 |