Table 3 Proteinuria reduction and treatment response in patients with iMN treated with Acthar gel
From: Acthar gel in the treatment of nephrotic syndrome: a multicenter retrospective case series
Patient | Previous IST/CT | Concurrent medications | Serum albumin | SCr | Proteinuria | Treatment response |
|---|---|---|---|---|---|---|
Pre-Acthar | Pre-Acthar | |||||
Pre-Acthar | Post-Acthar % change (mg/dL) | Post-Acthar % change (mg/d) | ||||
Post-Acthar (g/dL) | ||||||
1 | Prednisone, cyclophosphamide, rituximab | ARB, ACEI | 2.7 | 1.3 | 13,600 | Clinical response |
3.2 | 1.3 | 6600 | ||||
0 | −51.5 | |||||
2 | Prednisone, IVMP | Prednisone | 1.4 | 1.2 | 6354 | Partial remission |
3.3 | 1.1 | 1000 | ||||
−8.3 | −84.3 | |||||
3 | None | None | 1.5 | 2.5 | 15,400 | Partial remission |
3.1 | 1.9 | 2376 | ||||
−24.0 | −84.6 | |||||
4 | Prednisone, cyclosporine | ACE | 1.6 | 1.9 | 10,000 | Clinical response |
2.1 | 1.9 | 4000 | ||||
0 | −60.0 | |||||
5 | Prednisone | ARB, ACEI | 3.8 | 1.9 | 4000 | No response |
3.7 | 2.0 | 3475 | ||||
5.3 | −13.1 | |||||
6 | Tacrolimus | ACEI | 3.3 | 1.0 | 5500 | Complete remission |
3.4 | 0.9 | 349 | ||||
−10.0 | −93.7 | |||||
7 | Prednisone, tacrolimus, chlorambucil | ARB | 3.9 | 0.9 | 2400 | Complete remission |
Tacrolimus | 4.0 | 1.0 | 163 | |||
−11.1 | −93.2 | |||||
8 | Prednisone, cyclosporine | ACEI | 3.2 | 1.3 | 3070 | Early termination |
NA | NA | NA | ||||
NA | NA | |||||
9 | Prednisone, cyclosporine | ACEI | 3.8 | 2.1 | 1930 | Partial remission |
3.7 | 2.2 | 728 | ||||
4.8 | −62.3 | |||||
10 | Prednisone, tacrolimus, cyclophosphamide | ARB | 3.5 | 1.3 | 5210 | Partial remission |
3.7 | 1.6 | 1780 | ||||
23.1 | −65.8 | |||||
11 | Prednisone, IVMP, cyclophosphamide | ACEI | NA | 3.3 | 5132 | No response |
NA | 3.8 | 6600 | ||||
15.2 | 28.6 |