Table 5 Proteinuria reduction and treatment response in patients treated with Acthar gel, by etiologic diagnosis
From: Acthar gel in the treatment of nephrotic syndrome: a multicenter retrospective case series
Patient | Previous IST/CT | Concurrent medications | Serum albumin | SCr | Proteinuria | Treatment response |
|---|---|---|---|---|---|---|
Pre-Acthar | Pre-Acthar | Pre-Acthar | ||||
Post-Acthar (g/dL) | Post-Acthar % change (mg/dL) | Post-Acthar % change (mg/d) | ||||
MLN | ||||||
1 | Prednisone, cyclophosphamide | ACEI, prednisone | 1.8 | 1.0 | 8000 | Partial remission |
3.3 | 0.8 | 1089 | ||||
−20.0 | −86.4 | |||||
2 | MMF | ACEI | 1.7 | 1.0 | 19890 | Partial remission |
2.4 | 1.1 | 2454 | ||||
10.0 | −87.7 | |||||
MCD | ||||||
1 | Prednisone | ACEI | 3.7 | 0.9 | 2000 | Complete remission |
4.7 | 1.2 | 241 | ||||
33.0 | −88.0 | |||||
2 | Prednisone, cyclosporine | ACEI | 2.1 | 1.0 | 15000 | Complete remission |
2.3 | 0.7 | 89 | ||||
−30.0 | −99.4 | |||||
FGN | Prednisone, MMF, rituximab | MMF | 1.4 | 5.6 | 13000 | No response |
3.4 | 9.0 | 10000 | ||||
60.7 | −23.1 | |||||
MPGN | None | ACEI | 1.5 | 0.7 | 10000 | Partial remission |
3.3 | 0.8 | 2141 | ||||
14.3 | −78.6 | |||||
OTHERa | ||||||
1 UNS | Prednisone | None | 3.5 | 1.6 | 3000 | Clinical response |
4.6 | 2.2 | 1600 | ||||
37.5 | −46.7 | |||||
2 UNS | Prednisone | ACEI | 3.5 | 1.7 | 4500 | Partial remission |
4.0 | 1.9 | 2000 | ||||
11.8 | −55.6 | |||||
3 UNS | None | None | 3.1 | 1.3 | 5500 | Early termination |
3.3 | 1.3 | NA | ||||
0 | NA |