CA-AKI and RIFLE (n = 14) | CA-AKI (n = 9) | Only RIFLE (n = 31) | No CA-AKI (n = 95) | P value | |
---|---|---|---|---|---|
Age (years) | 73 [61–80] | 60 [48–67] | 68 [57–75] | 63 [55–71] | 0.08 |
Sex (male/female) | 10/4 | 6/3 | 22/9 | 55/40 | 0.55 |
ICU admission diagnosis (medical/surgical) | 11/3* | 7/2 | 29/2* | 77/18 | 0.41 |
APACHE II score | 26 [20–30]* | 21 [17–28] | 18 [11–26] | 20 [14–23] | 0.04 |
Weight (kg) | 80 [74–90] | 72 [60–88] | 84 [75–95]* | 75 [65–86] | 0.05 |
Diabetes mellitus (%) | 4 (29) | 2 (22) | 9 (29) | 26 (27) | 0.98 |
Nephrotoxic drugs | 5 (36) | 4 (44) | 14 (45) | 43 (45) | 0.92 |
Cardiovascular risk factors (%) | 11 (79) | 6 (75) | 23 (74) | 65 (68) | 0.86 |
Need for renal replacement (%) | 3 (21)* | 0 (0) | 3 (10)* | 0 (0) | <0.001 |
Length of ICU stay (days) | 15 [12–18] | 10 [6–19] | 8 [5–21] | 12 [8–23] | 0.42 |
ICU mortality (%) | 9 (64)* | 3 (33) | 9 (29) | 14 (15) | <0.001 |
Haematocrit (%) | 32 .2 [29.2–40.2] | 28.5 [24.8–33.0] | 32.1 [26.9–40.8] | 30.6 [27.1–36.6] | 0.37 |
Urea (mg/dL) | 50 [42–57] | 40 [31–54] | 40 [32–60] | 44 [32–58] | 0.57 |
Creatinine (mg/dL) | 1.18 [1.00–1.40]* | 0.80 [0.45–1.10] | 0.98 [0.74–1.18] | 0.84 [0.62–1.08] | 0.03 |
MDRD mL/min/1.73 m2 | 52 [46–71] | 80 [66–173] | 76 [52–92] | 82 [59–128] | 0.06 |
Patients with creatinine ≥1.5 mg/dL | 1 (9 %) | 1 (14 %) | 4 (12.9 %) | 9 (9.5 %) | 0.93 |
pH | 7.37 [7.30–7.42] | 7.42 [7.27–7.48] | 7.36 [7.30–7.42] | 7.42 [7.33–7.46] | 0.08 |
BE (meq/L) | −2 [−6–2] | 1 [−3–7] | −1 [−4–0] | 1 [−2–5] | 0.08 |
HCO3 (mmoL/L) | 22.9 [20.7–25.2] | 25.0 [23.5–31.4] | 24.0 [21.4–27.8] | 25.7 [22.0–30.3] | 0.29 |
Na (mEq/L) | 140 [136–142] | 138 [134–140] | 139 [137–143] | 140 [137–143] | 0.19 |
CPK (UI/mL) | 171 [91–854] | 203 [11–376] | 199 [49–604] | 117 [44–348] | 0.32 |
CRP (mg/dL) | 15.6 [6.6–22.8] | 8.7 [3.6–17.3] | 7.4 [0.5–13.0] | 9.3 [2.5–18.4] | 0.13 |
Lactate (mmol/L) | 1.0 [0.6–1.3] | 0.6 [0.5–0.9] | 0.4 [0.4–0.8] | 0.5 [0.5–0.7] | 0.11 |
Nephropathy prevention (%) | 2 (14.2) | 0 (0) | 6 (19.4) | 21 (22) | 0.41 |
Mean blood pressure before CM (mmHg) | 80 [64–94] | 70 [62–87] | 84 [74–91] | 81 [71–94] | 0.51 |
Mean blood pressure at 6 h (mmHg) | 72 [66–88] | 72 [60–79] | 77 [68–88] | 81 [71–96] | 0.10 |
Mean blood pressure at 12 h (mmHg) | 73 [64–74]* | 74 [68–80] | 74 [69–79] | 79 [70–88] | 0.02 |
Mean blood pressure at day 1 (mmHg) | 71 [65–74]* | 76 [69–80] | 74 [68–83] | 85 [74–97] | <0.001 |
Mean blood pressure at day 2 (mmHg) | 67 [64–77]* | 74 [68–77]* | 79 [71–86]* | 90 [79–98] | <0.001 |
Mean blood pressure at day 3 (mmHg) | 76 [69–88]* | 71 [65–85]* | 77 [69–88]* | 88 [77–100] | <0.001 |
CVP before CM (mmHg) | 10 [6–14] | 13 (11–14] | 10 [8–11] | 9 [5–11] | 0.14 |
Maximal vasopressor dose on the day of CM (mcg/kg/min) | 0.12 [0.00–0.20]* vs no | 0.00 [0.00–0.15] | 0.04 [0.00–0.12] | 0.00 [0.00–0.00] | 0.004 |
Maximal vasopressor dose, day 1 (mcg/kg/min) | 0.10 [0.05–0.40]* | 0.00 [0.00–0.06] | 0.00 [0.00–0.06] | 0.00 [0.00–0.00] | <0.001 |
Maximal vasopressor dose, day 2 (mcg/kg/min) | 0.19 [0.00–0.40]* | 0.00 [0.00–0.04] | 0.00 [0.00–0.08] | 0.00 [0.00–0.00] | <0.001 |
Maximal vasopressor dose, day 3 (mcg/kg/min) | 0.15 [0.00–0.30]* | 0.00 [0.00–0.09] | 0.00 [0.00–0.01] | 0.00 [0.00–0.00] | <0.001 |
Doses of CM (ml/kg) | 1.54 [1.47–5.38] | 1.64 [1.33–1.85] | 1.53 [1.17–1.61] | 1.60 [1.21–1.85] | 0.32 |
Diuretics on day of CM injection (%) | 1 (9 %) | 5 (71 %)* | 3 (12 %) | 7 (13 %) | <0.001 |
Fluid intake, day 0 (ml) | 3015 [2200–3885] | 2495 [1774–3030] | 2600 [2058–3516] | 2830 [2124–3814] | 0.65 |
Fluid intake, day 1 (ml) | 3371 [2125–4184] | 3371 [2125–4184] | 3085 [2005–3748] | 2865 [2098–3676] | 0.49 |
Fluid intake, day 2 (ml) | 3069 [1786–3780] | 2090 [1730–3369] | 2810 [2186–3124] | 2550 [1949–3395] | 0.78 |
Fluid intake, day 3 (ml) | 2640 [1738–3811] | 2750 [1820–3308] | 2285 [1628–3103] | 2465 [1690–3360] | 0.63 |